@npevolution

The Zhang lab studies (bio)chemical diversity of natural products and synthetic biology applications at Westlake University.

 Hangzhou, CN
Joined March 2022
  • Tweets49
  • Following83
  • Followers176
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NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining of Nonribosomal Peptides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining...

Abstract. Nonribosomal peptides serve as pivotal sources for drug discovery. Accurate prediction of the substrate specificity of adenylation domains in non

pubs.acs.org
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Breakthrough in Enzyme Engineering! Researchers from Westlake University published two back-to-back papers in Nature Chemical Biology, unveiling a novel approach to enzyme engineering that could revolutionize the way we manufacture complex chemical molecules. 👉nature.com/articles/s41589-0… 👉nature.com/articles/s41589-0… #WestlakeUniversity #ResearchAtWestlake #Chemistry #Innovation #Enzyme @Nature
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Out today at @ScienceMagazine - giant PKZILLA proteins spew huge polyketide marine toxins, just like #Godzilla! Witnessed by @photocyte & @VikShende at @Scripps_Ocean science.org/doi/10.1126/scie…

Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins

Prymnesium parvum are harmful haptophyte algae that cause massive environmental fish kills. Their polyketide polyether toxins, the prymnesins, are among the largest nonpolymeric compounds in nature...

science.org
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Lihan Zhang retweeted
Shen Lab@lab_shen3 Jun 2024
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio nature.com/articles/s41589-0…
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Move over titin... introducing PKZILLA as the largest protein in life that makes one the largest nonpolymeric compounds in biology, the marine polyether toxin prymnesin. Congrats to @photocyte & @VikShende and rest of team! biorxiv.org/content/10.1101/…

Giant polyketide synthase enzymes biosynthesize a giant marine polyether biotoxin

Prymnesium parvum are harmful haptophyte algae that cause massive environmental fish-kills. Their polyketide polyether toxins, the prymnesins , are amongst the largest nonpolymeric compounds in...

biorxiv.org
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Wishing you a wonderful spring for the new academic year! #WestlakeSeasons #WestlakeYunguCampus
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See how Yajie Wang’s synthetic biology and protein engineering team at Westlake University’s WangSynbio Lab is exploring the use of engineered enzymes and modified microbes to create a healthier, cleaner and more sustainable world. #WomenInScience #WomensHistoryMonth #HerWestlake
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A new review article by Martin Grininger (@Grininger_Lab) explores the enzymology of modular polyketide synthases. Free to read: rdcu.be/c7vZC nature.com/articles/s41589-0…
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Over 20 years ago, Bill Gerwick @GerwickL and I proposed this unusual biosynthetic route involving a single carbon truncation. Great to see the proof. Enzymatic α-Ketothioester Decarbonylation Occurs in the Assembly Line of Barbamide for Skeleton Editing pubs.acs.org/doi/10.1021/jac…

Enzymatic α‑Ketothioester Decarbonylation Occurs in the Assembly Line of Barbamide for Skeleton...

Abstract. The decarbonylation reaction has been developed significantly in organic chemistry as an effective approach to various synthetic applications, bu

pubs.acs.org
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Lihan Zhang retweeted
PKSpapers@PKS_papers17 Dec 2022
Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl-Substituted Aromatic Polyketides dlvr.it/SfVppd

Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl-Substituted...

Lorneic acid and related natural products are characterized by a trialkyl-substituted benzene ring. The formation of the aromatic core in the middle of the polyketide chain is unusual. We character...

pubmed.ncbi.nlm.nih.gov
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MIBiG version 3 is out! So grateful to the many dozens of people worldwide who helped annotate hundreds of new biosynthetic gene clusters, enzymes and molecules. Particular thanks go out to @BDragonMaster & @kaiblin for their efforts! Read the paper here: academic.oup.com/nar/advance…
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Worth reading: this important study by Martin Lohr and colleagues finally reveals the biosynthetic pathway of fucoxanthin: the pigment essential for light capture in ecologically relevant algae such as diatoms, haptophytes and brown algae! doi.org/10.1073/pnas.2203708…
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Exciting to share our most recent discovery on Polyvinyl Chloride Degradation by a Bacterium Isolated from the Larvae Gut of an agriculturally Invasive Pest first into China in early 2019 @Westlake_Uni @Westlake_SOE : nature.com/articles/s41467-0…
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Lab article: Complete biosynthetic pathway of the phosphonate phosphonothrixin. This study demonstrates an unprecedented use for thiamine diphosphate, an essential cofactor discovered more than 100 years ago! ByYuxun pubs.acs.org/doi/10.1021/jac…

Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosph...

Abstract. Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonot

pubs.acs.org
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Lihan Zhang retweeted
PKSpapers@PKS_papers25 Aug 2022
The Type III polyketide synthase supergene family in plants: complex evolutionary history and functional divergence dlvr.it/SXCjlL
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Lihan Zhang retweeted
Lena Barra@barra_lena17 Aug 2022
Wondering about building block delivery functions of enzyme cofactors in natural product biosynthetic pathways? Check our Perspectives Article @JACS_Au just published today: pubs.acs.org/doi/10.1021/jac…

Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis

Abstract. Enzymes involved in secondary metabolite biosynthetic pathways have typically evolutionarily diverged from their counterparts functioning in prim

pubs.acs.org
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Rui Wang, who has been named in MIT’s Innovators Under 35 for his work (technologyreview.com/innovat…), found that adding caffeine and its derivatives improved the stability of perovskite solar cells. @techreview @Westlake_SOE
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Super excited about this paper from the Youming Zhang and Xiaoying Bian labs! It gives new insights into Asp/His beta-hydroxylation in siderophores, and I'm happy to see experimental evidence supporting my genome-based hypothesis! (🧵 1/5 ) onlinelibrary.wiley.com/doi/…

Biosynthesis of Glidomides and Elucidation of Different Mechanisms for Formation of β‐OH Amino Acid...

Glidomides include two unusual amino acid residues: threo-β-OH-L-His and threo-β-OH-D-Asp. GlmD independently catalyzes the hydroxylation of L-Asp to primarily produce threo-β-OH-L-Asp on the...

onlinelibrary.wiley.com
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Lihan Zhang retweeted
TeufelLab@TeufelLab18 May 2022
Natural products biosynthesis is regulated by transcriptional regulators? Not always: Check out Marina's and Adelheid's work on an acetyltransferase that controls the metabolic flux in polyketide biosynthesis via acetylation of redox tailoring enzymes pubs.rsc.org/en/content/arti…

An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct...

The often complex control of bacterial natural product biosynthesis typically involves global and pathway-specific transcriptional regulators of gene expre

pubs.rsc.org
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Very pleased to announce that 24 methods and protocols for "Engineering Natural Products Biosynthesis" have just been published in Methods in Molecular Biology. A huge thank you to the 54 authors in 15 different countries who contributed. link.springer.com/book/10.10… 1/3

Engineering Natural Product Biosynthesis

link.springer.com
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