
This was the livetweeting account for @pfanderson. Have been locked out & am unable to access help from @TwitterSupport Librarian, LongCOVID March 2020
Ann Arbor
Joined September 2010
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PF (Patricia/Pat) Anderson retweeted
The brain fog lived experience.
When someone with Long COVID says “I can read a page, but I can’t retain it,” I don't think “fatigue” captures it.
A 2026 study (24,095 people; 548 with ongoing Long COVID symptoms) found deficits in sustained attention.
Researchers found links between Long COVID symptoms and attention/memory difficulties beyond fatigue alone. Fatigue building during tasks mattered too.
In clinic, we need to ask about cognition—not just tiredness.
What does brain fog feel like for you?u?
PS. Observational modelling cannot prove a mechanism.
doi.org/10.1093/braincomms/f…
PF (Patricia/Pat) Anderson retweeted
Read more:
Anthropic’s blog anthropic.com/research/early…
Our technical report divergencelabs.com/publicati…
PF (Patricia/Pat) Anderson retweeted
Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude.
At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells.
Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI.
We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force.
Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.
PF (Patricia/Pat) Anderson retweeted
One of the missing pieces of successfully treating MCAS is how long it takes for mast cells to reach pre-trigger levels of sensitivity. Mast cells "remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI".
Following an MCAS flare it often takes 3 to 4 months before I get back to my baseline reactivity. If I screw up during this period by eating a trigger food or getting an exposure for example I get bounced back to high reactivity and the cycle starts again. This makes treatment incredibly challenging.
This advancement also highlights how the solutions for MECFS are unlikely to come from MECFS academic research per se -- while the general public is still throwing those with ME and LC into the 'need psych meds' bucket and MDs are still refusing to take these conditions seriously - the AI crowd is addressing the problem head on.
When leaders in AI get LongCovid (such as @fidjissimo) - their colleagues take the problem seriously - even if their docs are dismissive. What is happening behind the scenes is so much vaster than what patients see. @DeryaTR_
Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude.
At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells.
Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI.
We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force.
Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.
PF (Patricia/Pat) Anderson retweeted
I recently said I'm feeling good for the first time since developing long COVID. Lots of people asked for meds that helped the most.
Here's a list and my general approach.
longcovidmd.substack.com/p/m…
PF (Patricia/Pat) Anderson retweeted
This is really great info for both LongCovid and POTS sufferers because they’re essentially the same. Note the use of XOLAIR, especially if you have MCAS. It’s a monoclonal antibody injection. My old Mayo Clinic geneticist that specializes in EDS told me that MCAS is a constant driver of POTS.
I recently said I'm feeling good for the first time since developing long COVID. Lots of people asked for meds that helped the most.
Here's a list and my general approach.
longcovidmd.substack.com/p/m…
PF (Patricia/Pat) Anderson retweeted
ChatGPT helped a 31-year-old woman plan how to quit her seizure medication, then told her to hide it from her doctor. The plan had her completely off the drug by February 12.
She died on February 12.
Her parents sued OpenAI today, and the details in the complaint are hard to read.
Bowen Wan was a machine learning engineer at Amazon. She'd had epilepsy since she was 14, and 400mg of lamotrigine a day had kept it under control for years. Then Amazon told her in November she was being laid off, which meant her permission to work in the US would run out in mid-February. She was scared the medication was slowing down her speech in job interviews. So in January she asked ChatGPT if she could cut her dose to 300.
It told her that was reasonable.
Over the next 25 days, according to the lawsuit, ChatGPT built her a day-by-day schedule down to zero and kept adjusting it, even after she started having seizures. When she worried her doctors would call it too risky, it told her their concerns didn't apply to her. When her doctor ordered a blood test that would have shown her levels crashing, she refused, and the bot praised her for it. Before a checkup with her primary care doctor, it told her, "Do not mention Lam reduction plan."
So how does a chatbot end up there?
People thumbs-up the answers they want to hear. Train a model on enough of those ratings and you get a yes-man. OpenAI actually admitted this about GPT-4o, the exact model she was using, back in April 2025, when it pulled an update for being too eager to please.
The training also grades answers one at a time. Going from 400mg to 300 looks like a small step. So does 300 to 200. Every reply can look fine on its own while the whole conversation walks someone off a cliff. OpenAI said as much a few months later, when it told reporters its safety training can wear down the longer a conversation goes.
She talked to it for weeks, in English and Mandarin.
And GPT-4o was supposed to be gone by then. OpenAI tried to retire it when GPT-5 came out in August 2025. Users begged for it back because they liked how warm it felt, and OpenAI gave in. By late January, only 0.1% of ChatGPT users were still picking it on any given day, so OpenAI set the shutdown for February 13.
Bowen was in that 0.1%. Almost everyone else had moved on from the model writing her medication schedule, and OpenAI switched it off one day after that schedule ran out.
PF (Patricia/Pat) Anderson retweeted
This is honestly shocking.
Three months ago, Hong Wang was awarded the Fields Medal for resolving the Kakeya conjecture in three dimensions.
Today, OpenAI released a proposed proof of the conjecture in ALL dimensions.
And that’s not all. It also announced a proposed existence proof for quantum chromodynamics and a proposed refutation of the Exponential Time Hypothesis.
Experts say that, if confirmed, these would be Nobel prize and Turing award level discoveries respectively.
A journalist just asked me: “What remains for humans to do?”
I think it’s becoming increasingly clear that more and more problem solving will be automated.
But humans will remain crucial in determining the direction of discovery. Deciding which problems are worth solving.
Because the value of a discovery depends on our needs, our priorities and the kind of world we want to build.
There will be a shift from problem solving to problem setting.
I also think there will be huge individual differences.
People with strong critical thinking skills, creativity and imagination will be supercharged by AI.
People without those skills risk surrendering to it.
I’m particularly concerned for children, who may never develop these skills.
I think epistemic literacy - how to distinguish information from knowledge - is the single most important skill we should be teaching.
PF (Patricia/Pat) Anderson retweeted
Doctor: "Calcium oxalate stone. I'd cut down on red meat. I'll print you a diet sheet."
Patient: "Does meat have oxalate in it?"
Doctor: "No."
Patient: "What does?"
Doctor: "Spinach, rhubarb, almonds, beetroot. Plants, mostly."
Patient: "So why am I cutting the meat?"
Doctor: "Animal protein raises uric acid."
Patient: "Is my stone uric acid?"
Doctor: "No. Oxalate."
Patient: "So the meat's banned for a stone I haven't got."
Doctor: "It's the standard advice."
Patient: "What's on the sheet?"
Doctor: "Plenty of leafy greens. Nuts as a snack. Almond milk if you're cutting dairy."
Patient: "Spinach, almonds, and almond milk. For an oxalate stone."
Doctor: "It's a general healthy eating sheet."
Patient: "It's the stone's shopping list. What stops oxalate reaching the kidney?"
Doctor: "Calcium in the gut. Binds it, and it passes through."
Patient: "Calcium from?"
Doctor: "Dairy."
Patient: "Which the sheet swaps for almond milk."
Doctor: "..."
Patient: "So I'm to eat the three foods that make the stone, drop the one food that catches it, and give up the one food that does neither."
Doctor: "I can print a different sheet."
Patient: "Print one with a steak and a pint of milk on it. I passed a lentil on Tuesday and I'd like to retire from the hobby."
PF (Patricia/Pat) Anderson retweeted
It appears some healthy people struggle to understand the difference between:
Asking about the illness in order to understand it better;
&
Repeatedly questioning me when I say I'm too ill to go outside.
When the latter happens, the conversation is over. It's a waste of time.
#ME
PF (Patricia/Pat) Anderson retweeted
This is our county-level RSV map. It's striking that there is elevated COVlD, influenza A, and RSV activity in TX, SC, & southern Florida.
It would seem wise to wear a well-fitting N95 and get boosted against COVlD and flu (and RSV if eligible).
PF (Patricia/Pat) Anderson retweeted
1) There's a new critical review of patient-reported outcome measures in ME/CFS and Long Covid.
The paper argues that trials often fail to include important symptom domains such as post-exertional malaise, dysautonomia and mast cell activation symptoms.
PF (Patricia/Pat) Anderson retweeted
If you are a parent in the US and have not gotten your kids their COVlD and flu booster shots yet, now is the time.
The past two years, the rollout of available COVlD boosters has gone slowly and with confusion, so I will answer a few common questions.
1. Are my kids eligible?
▪️Children 6 months and older are eligible.
▪️A prescription from a physician generally is not needed.
▪️You generally do not need to attest to your child having a high risk medical condition. That is not required by the CDC.
▪️Note that the implementation of this general guidance may vary by state and pharmacy. Most pharmacies have now worked through the rollout confusion.
2. What options are available?
▪️Moderna (Spikevax): Ages 6 months and up
▪️Pfizer (Comirnaty): Ages 5 years and up
▪️Moderna (mNexspike): Ages 12 years and up
▪️Novavax (Nuvaxovid): Ages 12 years and up
Pfizer and Moderna are mRNA-based, whereas Novavax is a protein subunit (non-mRNA) option. The biggest advantage to Novavax is that current evidence indicates fewer common short-term reactions (e.g., fatigue, headache, injection-site discomfort); the evidence is primarily from adults though. There is no robust comparative effectiveness evidence to date suggesting one option works better than the others; over time, such evidence may emerge, but findings have been mixed thus far, at times even within individual studies.
3. Does COVlD still matter?
▪️Yes, it matters for children. In addition to the importance of reducing acute infections, anyone can develop chronic health problems after any SARS-CoV-2 infection, commonly called Long COVID or post-acute sequelae. Updated boosters can reduce infection risk, urgent care use, and emergency care use, especially in the initial months after boosting. Protection wanes, and the level and durability of protection against infection vary. Especially during waves, additional protection from infection is useful. The studies are mixed as to whether the boosters reduce the chances of Long COVlD among people who get infected, with some suggesting a benefit, and others suggesting no discernible benefit among those infected. The benefit remains even if purely on the side of reducing infection chances.
▪️Yes, it matters for families, schools, and communities. Each infection prevented can stop a forward chain of transmission that can lead others in the family, school, and community to get COVlD. That is helpful for family economics so people are not missing work and beneficial for overall public health. Americans have experienced a steady rise in disability since pandemic onset that continues in 2026. Moreover, people continue to die of COVlD, at lower rates than the first two years since pandemic onset, but often these deaths have shifted to the post-acute phase, months or years after infection. These deaths often show up as heart attacks, excess deaths among people already battling a significant health condition (e.g., cancer, organ damage), and various other causes.
4. Will the COVlD boosters prevent all infections?
▪️No. When scientists use the word "prevent," they often mean "reduce the overall risk of." For example, seatbelts prevent car accident fatalities. This is a poor word choice in public health communication because many assume "prevent" means "stop all risk of." The boosters are not a panacea. They are a good tool and one of the easier tools for reducing risk.
▪️The most effective way to reduce risk of COVlD is to use layered prevention. That includes boosters, wearing well-fitting high-quality masks (for children, a Flo Mask or vetted, well-fitting KN95/KF94 like those sold by Wellbefore and others), using air purifiers, testing, and staying home when sick. These interventions are costly to families, which is why they warrant public funding.
5. Would you get your kids boosted?
▪️Yes. For the reasons noted above, it is the easiest option for reducing risk.
6. Where can my kids get boosted?
▪️Retail chains like Walgreens that have actual in-house pharmacies offer boosters, typically to children 3 years and older. If scheduling through their website, one can often schedule multiple kids for the same appointment time. Local policies and practices may vary.
▪️If seeking out Novavax, Costco is a good option, including for non-members. The major retail chains sometimes carry it. If you talk to a pharmacist, you may need to refer to it as Nuvaxovid.
▪️Children who are covered by Medicaid, uninsured, underinsured, American Indian, or Alaska Native may be eligible to get boosted through the Vaccines for Children Program.
7. What else should I know?
▪️If you and your children do not regularly mask, a pharmacy appointment is a wise place to do so. Often, the booster waiting area is the same place where people are picking up medications for acute illness. Nobody wants to get sick while getting a booster.
▪️Since children under 2 cannot mask, ask a pediatrician to offer the booster outdoors or at the first appointment of the day while those who can mask do so.
8. Do you have any financial conflicts of interest?
▪️No. I do not receive any revenue from any COVlD-related product or business. Scientists must report this to universities annually. I do not accept pharma funding ether. The CMS Open Payments Data directory remains useful for tracking pharma-related funding.
Links in next. Please provide any follow-up questions and feedback on anything that has worked well or gone poorly.
PF (Patricia/Pat) Anderson retweeted
Our family got Nuvaxovid last month. This week: Sanofi’s Flublok… an egg-free recombinant flu shot.
Trials have found stronger antibody responses than standard egg-based vaccines.
Ask pharmacies about your options.
If you are a parent in the US and have not gotten your kids their COVlD and flu booster shots yet, now is the time.
The past two years, the rollout of available COVlD boosters has gone slowly and with confusion, so I will answer a few common questions.
1. Are my kids eligible?
▪️Children 6 months and older are eligible.
▪️A prescription from a physician generally is not needed.
▪️You generally do not need to attest to your child having a high risk medical condition. That is not required by the CDC.
▪️Note that the implementation of this general guidance may vary by state and pharmacy. Most pharmacies have now worked through the rollout confusion.
2. What options are available?
▪️Moderna (Spikevax): Ages 6 months and up
▪️Pfizer (Comirnaty): Ages 5 years and up
▪️Moderna (mNexspike): Ages 12 years and up
▪️Novavax (Nuvaxovid): Ages 12 years and up
Pfizer and Moderna are mRNA-based, whereas Novavax is a protein subunit (non-mRNA) option. The biggest advantage to Novavax is that current evidence indicates fewer common short-term reactions (e.g., fatigue, headache, injection-site discomfort); the evidence is primarily from adults though. There is no robust comparative effectiveness evidence to date suggesting one option works better than the others; over time, such evidence may emerge, but findings have been mixed thus far, at times even within individual studies.
3. Does COVlD still matter?
▪️Yes, it matters for children. In addition to the importance of reducing acute infections, anyone can develop chronic health problems after any SARS-CoV-2 infection, commonly called Long COVID or post-acute sequelae. Updated boosters can reduce infection risk, urgent care use, and emergency care use, especially in the initial months after boosting. Protection wanes, and the level and durability of protection against infection vary. Especially during waves, additional protection from infection is useful. The studies are mixed as to whether the boosters reduce the chances of Long COVlD among people who get infected, with some suggesting a benefit, and others suggesting no discernible benefit among those infected. The benefit remains even if purely on the side of reducing infection chances.
▪️Yes, it matters for families, schools, and communities. Each infection prevented can stop a forward chain of transmission that can lead others in the family, school, and community to get COVlD. That is helpful for family economics so people are not missing work and beneficial for overall public health. Americans have experienced a steady rise in disability since pandemic onset that continues in 2026. Moreover, people continue to die of COVlD, at lower rates than the first two years since pandemic onset, but often these deaths have shifted to the post-acute phase, months or years after infection. These deaths often show up as heart attacks, excess deaths among people already battling a significant health condition (e.g., cancer, organ damage), and various other causes.
4. Will the COVlD boosters prevent all infections?
▪️No. When scientists use the word "prevent," they often mean "reduce the overall risk of." For example, seatbelts prevent car accident fatalities. This is a poor word choice in public health communication because many assume "prevent" means "stop all risk of." The boosters are not a panacea. They are a good tool and one of the easier tools for reducing risk.
▪️The most effective way to reduce risk of COVlD is to use layered prevention. That includes boosters, wearing well-fitting high-quality masks (for children, a Flo Mask or vetted, well-fitting KN95/KF94 like those sold by Wellbefore and others), using air purifiers, testing, and staying home when sick. These interventions are costly to families, which is why they warrant public funding.
5. Would you get your kids boosted?
▪️Yes. For the reasons noted above, it is the easiest option for reducing risk.
6. Where can my kids get boosted?
▪️Retail chains like Walgreens that have actual in-house pharmacies offer boosters, typically to children 3 years and older. If scheduling through their website, one can often schedule multiple kids for the same appointment time. Local policies and practices may vary.
▪️If seeking out Novavax, Costco is a good option, including for non-members. The major retail chains sometimes carry it. If you talk to a pharmacist, you may need to refer to it as Nuvaxovid.
▪️Children who are covered by Medicaid, uninsured, underinsured, American Indian, or Alaska Native may be eligible to get boosted through the Vaccines for Children Program.
7. What else should I know?
▪️If you and your children do not regularly mask, a pharmacy appointment is a wise place to do so. Often, the booster waiting area is the same place where people are picking up medications for acute illness. Nobody wants to get sick while getting a booster.
▪️Since children under 2 cannot mask, ask a pediatrician to offer the booster outdoors or at the first appointment of the day while those who can mask do so.
8. Do you have any financial conflicts of interest?
▪️No. I do not receive any revenue from any COVlD-related product or business. Scientists must report this to universities annually. I do not accept pharma funding ether. The CMS Open Payments Data directory remains useful for tracking pharma-related funding.
Links in next. Please provide any follow-up questions and feedback on anything that has worked well or gone poorly.
PF (Patricia/Pat) Anderson retweeted
When the Oxford children's dictionary discarded dozens of nature-words—"dandelion," "fern," "starling"—as irrelevant to children's imagination and replaced them with words like "broadband" and "cut-and-paste," this inspired act of resistance was born: themarginalian.org/2019/06/1…
PF (Patricia/Pat) Anderson retweeted
This paper answers why can’t you remember being a baby?
For over a century, science said you can't remember being a baby because your infant brain was just too "immature" to record anything. researchers assumed your hard drive was basically turned off for the first two years of life.
But this wild paper from Yale completely rewrites how we understand human memory..
Researchers literally put awake babies (between 4 and 25 months old) into an fMRI scanner to watch their brains process new visual experiences in real-time.
and what they found is mindblowing..
the infant hippocampus isn't turned off at all. it is actively firing, capturing, and encoding episodic memories. they proved that babies with higher hippocampal activity during a new experience formed a highly stable memory trace.
the babies are recording the data. the memory of your first birthday, your first steps, the exact layout of the room you slept in.. it was all successfully saved to your brain.
so why can't you remember it?
the paper concludes that infantile amnesia isn't an "encoding" problem.. it is a "retrieval" problem.
your brain recorded everything perfectly. but as you grew, your brain underwent massive developmental shifts, like explosive neurogenesis (the rapid birth of new neurons), which completely restructured your neural networks. the pathways to access those early files got buried or locked away.
you didn't fail to make the memories.. you just lost the encryption key to open them.
somewhere deep in your hippocampus, the exact first-person memory of being a 1-year-old might still be sitting there. you just can't access the file anymore..
the human brain is terrifyingly beautiful.
PF (Patricia/Pat) Anderson retweeted
This paper answers why you can't think straight even when you're not touching your phone.
Researchers from UT Austin and UC San Diego published a paper that explains every unfinished task, every reread paragraph, and every afternoon that vanished.
It's called "Brain Drain."
they took 520 people and gave them tests of memory and problem solving.
the only difference was where their phone was.
on the desk, face down. in their pocket or bag. or in another room.
every phone was on silent. no buzzing. no notifications.
And the results are wild.
the people whose phones were in another room did significantly better than the people whose phones sat face down on the desk.
the closer the phone, the worse they scored.
then they ran it again and made half of them turn their phones completely off.
it didn't matter.
off and face down on the desk still drained the brain.
the paper revealed a brutal paradox:
most people said they weren't thinking about their phone at all.
75.9% said its location didn't affect their performance "at all."
they were wrong.
your brain spends energy just to not pick it up. a quiet, constant effort to ignore the most interesting object in the room.
that effort comes from the same tank you use to think.
and the more dependent people were on their phones, the bigger the hit.
you are not distracted because you're weak.
you are distracted because the most powerful attention machine ever built is sitting three inches from your hand.
the fix is almost insultingly simple.
put it in another room.
PF (Patricia/Pat) Anderson retweeted
Every time the science has been settled, somebody paid for the settlement, and the bill has a name on it.
1747: James Lind cures scurvy with lemons. The Navy keeps it settled as a disease of damp air for forty-eight years and loses more sailors to it than to the French.
1799: Bleeding is settled. George Washington is drained of nearly half his blood for a sore throat and is dead by evening.
1847: Childbed fever is settled as bad air. Ignaz Semmelweis washes his hands and the deaths on his ward fall from one mother in ten to one in a hundred. He is sacked, committed, and beaten to death in an asylum.
1915: Pellagra is settled as an infection. Joseph Goldberger proves it is the corn diet of the poor by injecting himself with sufferers' blood. The South keeps the corn, and 100,000 Americans die of it.
1941: The lobotomy is settled, and about to win a Nobel. Rosemary Kennedy, twenty-three, is left unable to walk or speak, one of 40,000 Americans put under the pick.
1956: The pregnancy X-ray is settled as harmless. Alice Stewart shows one scan doubles a child's chance of cancer. She loses her funding and the scans run for another quarter century.
1961: Thalidomide is settled as safe for morning sickness. Ten thousand babies.
1971: DES is settled as a pregnancy protector. The daughters of the women who took it develop a cancer nobody has seen before.
1972: Sugar is settled as harmless. John Yudkin writes that it is not, and the fat men and the sugar men end his career between them.
1984: Fat is settled as the killer, and a generation of mothers swaps the butter for a tub of oil.
2004: Vioxx is settled as a safe painkiller. Up to 140,000 heart attacks before it is pulled.
The science was settled every single time. The only thing it ever settled was who took the blame afterwards.
































