Ranjit Joseph (@ranj585) header
Ranjit Joseph (@ranj585) profile picture

Husband. Dad to 3. Hematologist/Oncologist. Children’s book author. “Because I Love to Read” available on Amazon 🔗 ⬇️

North Carolina, USA
Joined March 2015
Photo by Ranjit Joseph (@ranj585)Photo by Ranjit Joseph (@ranj585)Photo by Ranjit Joseph (@ranj585)
Replying to @Prime_PBM
@Prime_PBM @CaterpillarInc why deny approval of Tucatinib a patient with locally advanced unresectable HER2 3+ rectal cancer who has progressed rapidly through first line chemotherapy!??! Your approval indications do not along with current FDA approvals! @mcuban
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I <3 my ‘26 @Tesla MY w FSD v14.2.2.2. This tech is going to save a lot of lives when more widely adopted. Feels amazing to be contributing to the FSD training miles for AVs. My only complaint is their maps/nav is not the best. Hopefully will be> google/apple maps over time.
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Need the GI onc hive opinion: 43 yo M, PS 0, stg IV G3 Large cell-NEC cecum w extensive liver Mets (causing transaminitis) & TLS. Admitted & started C1 Carbo/etop. NGS pending. Leaning 2ward Carbo/Etop/nivo then nivo. Wwyd? @GIMedOnc @GIcancerDoc @TumorBoardTues @AmanChauhanMD
50%Carbo/etop for 6 cycles
32%Carbo/Etop/IO—>IO maint
0%Pivot to Ipi/nivo now
18%Carbo/etop->Ipi/niv w POD
22 votes • Final results
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Looks like Carbo/etop & adding IO based on biomarkers from pending NGS makes the most sense given available data. Pivot to breakwater if BRAF. Ipi/nivo vs FFX as next line. TY all for your insight! Seems GI NENs are increasing in young people, not just CRC.
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In June (w/ ASCO abstract in hand) I tried 2 get Durva approved for my pt(PR after CRT for LS-SCLC). Peer to peer, 2 appeals,Mayo Clinic 2nd op agreeing w/ me,❤️ use request, all got denied. Pt progressed now & is getting a percardio💉 tomorrow😥 sad!@BlueCrossNC @marklewismd
🚨Out today #ADRIATIC @NEJM one of the most impactful @ASCO -Lung presentations this year: Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer | ⚡️New standard of care⚡️ N=760 ▶️Durvalumab x2 yrs post CRT ⬆️mOS: 56 vs 33mos (HR 0.74) ⬆️mPFS: 16.6 vs 9.2 mos (HR 0.76) @DavidRSpigel #lcsm 🚨Out today #ADRIATIC @NEJM one of the most impactful @ASCO -Lung presentations this year: Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer | ⚡️New standard of care⚡️ N=760 ▶️Durvalumab x2 yrs post CRT ⬆️mOS: 56 vs 33mos (HR 0.74) ⬆️mPFS: 16.6 vs 9.2 mos (HR 0.76) @DavidRSpigel #lcsm nejm.org/doi/full/10.1056/NE…
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My first children’s book based on my daughters is a heartwarming story about two sisters who jump into a magical book and show us what all we can learn through the power of books! Free on Kindle unlimited. Check it out! @purviparwani @drsanjaygupta amazon.com/gp/aw/d/B0CQL8NCQ…
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Out of oncology clinic I’m a full on girl dad and today I published my first children’s book that I wrote for my girls! You can follow my author page here for more book updates and future plans! Link to book in comments. #becauseilove #becauseilovetoread #childrensbooks
During bedtime w/ my babies I would make up silly rhymes to create a positive environment before we read books! When my daughter asked me about a rhyme from other night and I couldn't remember it, I knew I had to start writing them down. Today - the book is published on Amazon!
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Thinking a lot about #regretminimizationframework lately and @SahilBloom just nailed it!
I made a list of 10 things I know I’d regret on my deathbed. It was illuminating and inspiring. Here’s my list (and why everyone should make one):
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Compared with anticoagulation, left atrial appendage occlusion was assoc w/ a ~50% ⬇️ in the risk of death, ~35% ⬇️ in stroke or embolism and a ~20% ⬇️ in the risk of long-term 🩸 events. @purviparwani @GoRedForWomen Is this practice changing or awaiting #ClosureAF ?
#OriginalResearch: Left atrial appendage occlusion was associated with a lower risk of death, stroke and bleeding compared to anticoagulation among females and males @EmilyZeitler @JonHsuMD @AndreaRussoEP @drdevignair @djdardenMD @MCoylewright ahajrnls.org/41eMXif
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48 y/o F, Rt sided colon ca compressing Rt Ureter,LNs enlarged. P/w urosepsis, AKI & type II MI. C-scope + colon adeno, p-MMR. s/p ureteral stent. Mass abuts ext iliac artery. Per surgery, R0 resection unlikely. cT4N1. What would you do? @TumorBoardTues @doctorC369 @GIcancerDoc
2%Surg->adj chemo
2%Surg+IORT->chemo
52%Neoadj FOLFOX/CAPOX->surg
43%Neoadj FOLFIRINOX -> surg
83 votes • Final results
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Urosepsis and AKI resolved s/p stent and Abx. Excellent PS. primary mass growing extrinsically and abutting iliopsoas as well as Rt EIA. Clinical picture suggestive of BRAF+ . If neoadj FOLFOX, will it be enough to give a response needed for R0 resection?
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Replying to @TumorBoardTues
@TumorBoardTues (on Thursday) fellow GI onc docs, do you use “icing” (ice chips & cryotherapy for 🙌 and 🦶 ) during oxaliplatin to prevent 🥶 sensitivity? significant QOL issue for pts on oxali. Read at @colontown many providers & pt find 🧊ing helpful. Is there a protocol?
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Hey @mcuban , does @costplusdrugs have contracts to allow hospital to buy all their generic drugs in bulk ? Is buying from your site already cheaper than 340b/non340b pricing that many hospitals get. Also Need more generic cancer drugs. definitely sharing this with my patients!
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Let's take steps together at PurpleStride! support.pancan.org/site/TR?v…
Replying to @elonmusk
@elonmusk @ARKInvest @TashaARK @stevenmarkryan , @POTUS @VP this adorable 3 year old has drunk the kool-aid. Here’s our conversation about what she would do in her first 100-days as president.
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Fast, safe, mass sterilization of N95s with >99% efficiency led by a husband and wife team, Drs John and Raju along w/ NASA. @BillGates, @melindagates @drsanjaygupta, this needs our attention before big gov contracts drown out good science. nasa.gov/press-release/glenn…
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