Professor studying the transport and storage of lipids at UT Health, Houston, USA and Sydney, Australia. Basketball, tennis. Opinions are my own. He/him.
Houston and Sydney
Joined January 2010
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Thanks to @AZadoorian22 for finishing up this review. Lipid droplets are connected with many disease conditions. Here we summarize the latest on the biogenesis and functions of lipid droplets. We discuss a key role for lipid droplets in alleviating cellular stresses.
Want to know the latest about #LipidDroplet biogenesis and functions in health and disease?
Check out our @NatureRevEndo paper published online today! rdcu.be/dcODg
Thanks @rob8yang for the absolute privilege and joy of writing this with you and @ximingDu!🧵
ALT Proposed mechanisms of eukaryotic lipid droplet biogenesis
Hongyuan Rob Yang retweeted
A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER, which converts small lipid changes into a cooperative transcriptional response.
biorxiv.org/content/10.64898…
Hongyuan Rob Yang retweeted
With so many great reviews on LDs already out, do we need another?
Sarah @cohenlaboratory & I were approached by @NatRevMCB to organize a review on LD heterogeneity and inter-organelle contacts...topics often in reviews, but not a focus. Fun project!
nature.com/articles/s41580-0…
Hongyuan Rob Yang retweeted
The NHMRC yesterday announced final allocations for the year. The 2025 success rate for Ideas grants was 10%, Investigator grants 13%, and Clinical Trials 9%.
Australia's total spend on healthcare and technology innovation in medicine and biotech from the Medical Research Endowment Account and Medical Research Future Fund this year will equate to the cost of 0.004 submarines.
We're spending more on a single submarine than we'll spend on medical research in 30 years.
Medical research matters. A clever country invests in the things that matter.
We wrote a Perspective on the Cover story below. Check it out here science.org/doi/10.1126/scie…
Adipocytes have developed a unique regulatory mechanism to produce giant, unilocular lipid droplets.
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more in this week's issue: scim.ag/47FPKoj
ALT Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.
Great to see you. Also a wonderful visit. I have more scientific friends in Dallas than any other city on this planet.
We built upon a key discovery made by @KivancBirsoy and unveiled additional mechanisms for regulating lipid synthesis. CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis | PNAS pnas.org/doi/10.1073/pnas.25…
Thanks to @pnas for a nice commentary on our recent work by @LabVanni Toward a molecular logic of lipid droplet heterogeneity? | PNAS share.google/RBrrQE3o0942xaw…
Glad to see this online. From a random control experiment， we unexpectedly noticed that CIDE proteins and LD-localized ORP proteins cannot coexist on LDs. Through a series of experiments, we show that ORP2/5 keeps CIDE proteins away from LDs by depleting LD surface PI(4)P.
PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis | PNAS pnas.org/doi/10.1073/pnas.25…
Hongyuan Rob Yang retweeted
Dr. Jack Hu (胡仕新): “More than 40 years ago, I came to America to pursue a dream, arriving at the @UMich with a small suitcase and a thirst for learning. But never in my wildest dreams I’d imagine that I would became the chancellor of @UCRiverside ” 👍
latimes.com/california/story…
Hongyuan Rob Yang retweeted
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41586-0…
full text available here 👉 rdcu.be/em0VG and thread 👇
See you in Spain
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@EMBO
@Co_Biologists
meetings.embo.org/event/25-l…
This is brilliant
Lebron and Steph heading back to their mediocre teams to fight for a play-in spot
xitter.cf/YeahViva41550/status/1…
Hongyuan Rob Yang retweeted
New Wave of Alzheimer’s Therapies Actively Engage the Immune System biospace.com/drug-developmen…
Hongyuan Rob Yang retweeted
Heartiest congratulations @OlzmannLab . Have enjoyed following your journey from uber talented postdoctoral researcher to world leader in your field. I’m sure the best is still to come!
Thrilled to have been promoted to full professor @UCBerkeley! Thank you to all the members of my lab (past and present), my family, and my colleagues at UC Berkeley and beyond. Shout out to @DanNomura @RobertoZoncu @RapeLab @SJD956. What a journey! Very thankful. ☺️❤️
Hongyuan Rob Yang retweeted
Exciting story on adipogenin regulation of seipin complexes and lipid droplets in adipocytes from the Scherer lab @UTSWMedCenter! Beautiful story from discovery to structure to physiology. Very interesting seipin-ADIG cryo-EM structures! 🤩 biorxiv.org/content/10.1101/…
