Roberta Peruzzo (@roberta_peruzzo) profile picture

Roberta Peruzzo

@roberta_peruzzo

Postdoc in the Zoncu lab @berkeleymcb | PhD @unipadova

 Berkeley, CA
Joined June 2021
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  • Following90
  • Followers58
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Photo by Roberta Peruzzo (@roberta_peruzzo)
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41586-0… full text available here 👉 rdcu.be/em0VG and thread 👇
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

Nature - PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver...

nature.com
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🧠 Just out in Nature: A human brain map of mitochondrial diversity. A powerful collaboration with Mosharov and @MitoPsychoBio. Big step toward bridging cell biology and neuroimaging! 🔗 nature.com/articles/s41586-0… 🧬 #MitoBrainMap #neuroscience
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Roberta Peruzzo retweeted
Roberto Zoncu (@RobertoZoncu) profile picture
Roberto Zoncu@RobertoZoncu27 Mar 2025
Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain @aakritijain24 and amazing collaborators @rushika_perera, Guido Bommer, Charly Craik and @OlzmannLab: science.org/doi/10.1126/scie…
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic...

science.org
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Honored to receive the Leonardo Da Vinci Award in Life Sciences from the Leonardo da Vinci Society! Grateful to @issnaf @ISSNAF_BayArea and the @VinciSociety for this prestigious recognition of my work. Thank you for supporting researchers and innovation. #award #lifesciences
Image from Roberta Peruzzo (@roberta_peruzzo)
Image from Roberta Peruzzo (@roberta_peruzzo)
Image from Roberta Peruzzo (@roberta_peruzzo)
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Roberta Peruzzo retweeted
GiacomelloLab (@GiacomelloLab) profile picture
GiacomelloLab@GiacomelloLab18 Dec 2024
Image from GiacomelloLab (@GiacomelloLab)
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Thrilled to present the structure of mTORC1 on membrane. We are at an exciting time of using SPA to resolve high-resolution structures of complexes that land on the surface of membranes! Looking forward to seeing what can be done for this research frontier in the near future!
Hurley Lab (@TheHurleyLab) profile pictureHurley Lab@TheHurleyLab16 Nov 2024
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
Image from Hurley Lab (@TheHurleyLab)
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Roberto Zoncu (@RobertoZoncu) profile pictureRoberto Zoncu@RobertoZoncu4 Apr 2024
Good day for the lab, celebrating @AlexMayaRomero2 's @NSF-GRFP fellowship and @roberta_peruzzo's @AmericanCancer ACS postdoctoral fellowship, plus NOA for a new @NIH_NINDS R01!
Image from Roberto Zoncu (@RobertoZoncu)
Image from Roberto Zoncu (@RobertoZoncu)
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Thank you @issnaf and @ItalyinUS for the amazing experience!
Italy in US (@ItalyinUS) profile pictureItaly in US
@ItalyinUS9 Nov 2023
Italian scientists and researchers in the US express endless potential to step up Italy-US 🇮🇹🇺🇸 cooperation in science, tech, and innovation. Grazie @issnaf for the key role you and your members play!
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Roberto Zoncu (@RobertoZoncu) profile picture
Roberto Zoncu@RobertoZoncu26 Oct 2023
My amazing lab threw a surprise celebration for my recent promotion to full professor! I'm so grateful and fortunate to work with such smart, creative and caring people. This milestone is theirs as much as mine, and I look forward to helping them achieve ever greater heights!
Image from Roberto Zoncu (@RobertoZoncu)
Image from Roberto Zoncu (@RobertoZoncu)
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Very excited to see this finally out @Nature! It's been quite a journey making the story come true and visualizing the megacomplex! Great collaboration @G_Napolitano and twitterless Mariana de Araujo and Ballabio and Huber labs!
Hurley Lab (@TheHurleyLab) profile pictureHurley Lab@TheHurleyLab25 Jan 2023
We're excited to share the mTORC1-TFEB-Rag-Ragulator megacomplex online @Nature. A great collaboration with @G_Napolitano and twitterless Mariana de Araujo and Ballabio and Huber labs to shed light on mTORC1 regulation of #lysosome biogenesis and #autophagy! Thread below:
Image from Hurley Lab (@TheHurleyLab)
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Roberta Peruzzo retweeted
FrezzaLab (@FrezzaLab) profile picture
FrezzaLab@FrezzaLab7 Jan 2023
Lactate metabolism is essential in early-onset mitochondrial myopathy science.org/doi/10.1126/scia…
Lactate metabolism is essential in early-onset mitochondrial myopathy

Lactate metabolism is essential in early-onset mitochondrial myopathy

Metabolic analysis in an animal model of severe mitochondrial myopathy reveals a surprising dependence on lactate usage.

science.org
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Roberto Zoncu (@RobertoZoncu) profile picture
Roberto Zoncu@RobertoZoncu2 Oct 2022
Amazing lab retreat at Donner lake. Grateful to work with this group of brilliant young scientists!
Image from Roberto Zoncu (@RobertoZoncu)
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Hurley Lab (@TheHurleyLab) profile picture
Hurley Lab@TheHurleyLab14 Sep 2022
It’s out! Extrodinary work from Rachel Jansen @rachelmjansen is out today in Science Advances @ScienceAdvances
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Hurley Lab (@TheHurleyLab) profile picture
Hurley Lab@TheHurleyLab13 Sep 2022
🚨New preprint🚨Hurley lab #CryoEM master Chen Cui @Chen3dem presents the TFEBulator mega-complex. His structure identifies a non-canonical structural role for the Rag-Ragulator complexes in the phosphorylation of TFEB by #mTOR.
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Roberta Peruzzo retweeted
Roberto Zoncu (@RobertoZoncu) profile picture
Roberto Zoncu@RobertoZoncu25 Aug 2022
science.org/doi/10.1126/scie… Excited to share our new work out today in @ScienceMagazine, led by stellar postdoc Regina @hijaishin! We report the discovery of LYCHOS, a candidate cholesterol sensor for the mTORC1 kinase. Below is a brief summary of the story.
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

A cholesterol sensor for the growth regulator protein kinase complex mTORC1 is identified.

science.org
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Happy to share the preprint of this beautiful collaborative work! Thanks @RobertoZoncu and @TheHurleyLab!
Roberto Zoncu (@RobertoZoncu) profile pictureRoberto Zoncu@RobertoZoncu29 Jun 2022
Glad to have contributed to this beautiful structural and functional study on the active FLCN complex by Rachel Jansen & @TheHurleyLab, with really nice cell biology by Roberta @roberta_peruzzo!
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CRC_1218 (@CRC_1218) profile picture
CRC_1218@CRC_121820 Sep 2021
🗓️ #mitoawarenessweek Mitochondria generate the majority of energy for cells. These small organelles were discovered in 1857. Today special dyes are used to study their structure and shape. In this example, super-resolution #microscopy reveals the mitochondrial cristae.#wmdw
Image from CRC_1218 (@CRC_1218)
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