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DrMilosSimic (@DrMilosSimic) profile picture

DrMilosSimic

@DrMilosSimic

Synthetic immunologist building therapies for šŸ§  diseases. Assistant Professor at UChicago. Postdoc at UCSF in Wendell Limā€™s lab. PhD work with Andrew Dillin

Joined February 2019
  • Tweets36
  • Following951
  • Followers140
A new grant from @Biohub will help @UChicagoPME Asst. Prof. @DrMilosSimic advance research aimed at detecting neurodegenerative diseases like Alzheimerā€™s and Parkinsonā€™s decades before cognitive decline appears. šŸ”— Read more: ms.spr.ly/6018vu52y #Biohub #UChicago #Alzheimers #Parkinsons
Headshot of a man in a suit above text: LATEST NEWS. Biohub grant to boost early detection for Alzheimer's, Parkinson's.

ALT Headshot of a man in a suit above text: LATEST NEWS. Biohub grant to boost early detection for Alzheimer's, Parkinson's.

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Thrilled and honored to share that the Simic Lab has been selected as one of 15 teams worldwide to receive a synthetic biology grant from Biohub! šŸŽ‰ Thank you! More here: biohub.org/blog/immune-cell-ā€¦ and pme.uchicago.edu/news/biohubā€¦
The immune cell engineers

The immune cell engineers

Meet the scientists building tomorrow's medicine at Biohub.

biohub.org
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Weā€™re happy to welcome @DrMilosSimic as a Neubauer Family Assistant Professor of Molecular Engineering at @UChicagoPME! Dr. Simic is a synthetic immunologist and his research focuses on combining cell engineering and synthetic biology to understand and treat brain diseases. Welcome to the University of Chicago Pritzker School of Molecular Engineering, Milos! Learn more: pme.uchicago.edu/news/engineā€¦
Image from UChicago Pritzker Molecular Engineering (@UChicagoPME)
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šŸšØ New Preprint šŸšØ A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.06.05.6ā€¦
Image from Kyle G Daniels (@ScienceKyle)
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Why test #celltherapies one-by-one when you can use multiplexed #SynBio, #proteinengineering & #ML to design, measure & track them at scale? The Goodman Lab @PennMedicine opens July 2025. Weā€™re hiring Specialists & Postdocs! Apply @ bit.ly/42BnJNJ RTs appreciated!šŸ™
Image from Daniel Bryan Goodman (@dbgoodman)
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DrMilosSimic retweeted
Justin Eyquem (@j_eyquem) profile picture
Justin Eyquem@j_eyquem5 Feb 2025
šŸšØExcited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step šŸ§µšŸ‘‡ šŸ”— nature.com/articles/s41587-0ā€¦
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci

Nature Biotechnology - Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.

nature.com
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Ligand-restricted synNotch switches enable precision cell therapy dlvr.it/THcbMP #immunology
Image from Trends in Immunology (@TrendsImmuno)
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DrMilosSimic retweeted
OncoDaily (@oncodaily) profile picture
OncoDaily
@oncodaily1 Jan 2025
Why treating neurological disorders like brain tumors is difficult - @PatrickHwuMD (@MoffittNews) @DrMilosSimic oncodaily.com/insight/patricā€¦ #Health #Medicine #Cancer #OncoDaily #Oncology #BrainTumors
Patrick Hwu: Why treating neurological disorders like brain tumors is difficult - OncoDaily

Patrick Hwu: Why treating neurological disorders like brain tumors is difficult - OncoDaily

Patrick Hwu: Why treating neurological disorders like brain tumors is difficult / blood-brain barrier, brain tumors, cancer, Hideho Okada, Milos Simic,

oncodaily.com
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#ScienceSaturday Treating #neurological disorders like #brain tumors is difficult in part due to a protective ā€œwallā€ called the blood-brain barrier, meant to block toxins from reaching brain cells. āž”ļø In this study, @DrMilosSimic, @NishRReddy, Et al. developed brain-sensing T cells, engineered to deliver brain tumor-specific chimeric antigen receptors upon sensing the brain tumor microenvironment. āž”ļø This approach could pave the way for safer and more effective treatments for diseases like brain tumors, brain metastases, neuro-inflammation and more. šŸ”— Here's a link to the full article: science.org/doi/10.1126/scieā€¦
Image from Dr. Patrick Hwu (@PatrickHwuMD)
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DrMilosSimic retweeted
ACIR (@ACIR_org) profile picture
ACIR
@ACIR_org18 Dec 2024
From suppressing unwanted immunity to inducing immunity where it counts, SynNotch-engineered T cell can carry diverse payloads to specific locations, allowing for customized effects in numerous treatments bit.ly/4gfNUh8 @DrMilosSimic @CDI_UCSF @parkerici @NishRReddy
Image from ACIR (@ACIR_org)
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Big news today: 2 papers and the cover of @ScienceMagazine! @NishRReddy et al. built T cells that suppress inflammation in specific tissues science.org/doi/10.1126/scieā€¦ @DrMilosSimic, Payal Watchmaker et al. built T cells that deliver therapies to the brain science.org/doi/10.1126/scieā€¦
Image from Cell Design Institute @UCSF (@CDI_UCSF)
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HUGE congratulations to my labmates @NishRReddy and @DrMilosSimic!! Making waves so big we almost had a tsunami today šŸŒŠ
Cell Design Institute @UCSF (@CDI_UCSF) profile pictureCell Design Institute @UCSF@CDI_UCSF5 Dec 2024
Big news today: 2 papers and the cover of @ScienceMagazine! @NishRReddy et al. built T cells that suppress inflammation in specific tissues science.org/doi/10.1126/scieā€¦ @DrMilosSimic, Payal Watchmaker et al. built T cells that deliver therapies to the brain science.org/doi/10.1126/scieā€¦
Image from Cell Design Institute @UCSF (@CDI_UCSF)
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DrMilosSimic retweeted
Nish Reddy (@NishRReddy) profile picture
Nish Reddy@NishRReddy5 Dec 2024
THANKS TO THE TEAMS! Synthetic suppressor cell study by Lim Lab @CDI_UCSF @HebrokLab @AParent_lab @MaachiHasna @lillian_xyn @AtUcsf et al. Brain GPS study led by @DrMilosSimic Payal + @OkadaLabUCSF1 @parkerici @UCSF @OlgaTroyanskaya et al and now progressing to clinical trial.
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DrMilosSimic retweeted
Nish Reddy (@NishRReddy) profile picture
Nish Reddy@NishRReddy5 Dec 2024
šŸ§­ TISSUE GPS | We designed tissue-sensing cells to deliver therapies specifically to the brain. This ā€˜brain GPSā€™ increases therapeutic specificity + efficacy to potentially treat diverse neurological diseases, including glioblastoma or multiple sclerosis. doi.org/10.1126/science.adl4ā€¦
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Check out our latest work on building ā€œsmart cellsā€ with a tissue GPS to precisely treat some of the most challenging diseases without off-target toxicity. Brain targeting: science.org/doi/10.1126/scieā€¦ T cells with new immunosuppressive functions: science.org/doi/10.1126/scieā€¦
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P. Watchmaker, S. Gupta, Y. Wang, S. Sagan, J. Duecker, C. Shepherd, D. Diebold, P. Pineo-Cavanaugh, J. Haegelin, R. Zhu, B. Ng, W. Yu, Y. Tonai, L. Cardarelli, N. Reddy, S. Sidhu, O. Troyanskaya, S. Hauser, M. Wilson, S. Zamvil, H. Okada, and W. Lim
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Thank you for the nice perspective highlighting our work: science.org/doi/10.1126/scieā€¦ And the cover: science.org/toc/science/386/ā€¦ Thank you to all the authors for this awesome work! It has been a fantastic journey!
Synthetic gene circuits drive disease-fighting T cells

Synthetic gene circuits drive disease-fighting T cells

Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease

science.org
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Thrilled to announce the Lawrence Lab will open its doors within UCLA Biological Chemistry @BC_UCLA in January 2025! I couldnā€™t be more excited!
UCLA Biological Chemistry (@BC_UCLA) profile pictureUCLA Biological Chemistry@BC_UCLA6 Aug 2024
We are thrilled to announce that Dr. Rosalie Lawrence @ScienceyRosalie will join our department as our newest faculty member in January 2025! Her innovative research will greatly enhance our academic community. We look forward to welcoming you to @dgsomucla @UCLA Rosalie!
Image from UCLA Biological Chemistry (@BC_UCLA)
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Dr. Milos Simic @DrMilosSimic from Dr. Wendell Lim's lab @UCSF discusses harnessing CNS sensors to direct T cells towards brain tumors and other brain disorders. #IOTNCapstoneMeeting
Image from Cancer Immunoprevention Network (@NCI_CIPNet)
Image from Cancer Immunoprevention Network (@NCI_CIPNet)
Image from Cancer Immunoprevention Network (@NCI_CIPNet)
Image from Cancer Immunoprevention Network (@NCI_CIPNet)
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Dr. Ricardo Almeida @doraric of @CDI_UCSF shares their translational development (cleared by FDA for phase I clinical trial) of synNotch-CAR T cells for treatment of Glioblastoma - a fatal brain tumor, and potentially for other types of tumors. #Immunotherapy #IOTNSCMeeting
Image from Cancer Immunoprevention Network (@NCI_CIPNet)
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