@GuilleminLab

Investigating assembly, dynamics, and function of host-microbe systems. META Center for Host-Microbe Systems Biology Institute of Molecular Biology

 University of Oregon
molbio.uoregon.edu/guillemin/
Joined May 2021
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  • Following36
  • Followers152
Mucin-binding adhesins: A key to unlocking the door of mutualism. @Goo9Han @ShipraVaishnava highlight work of @tjarrods @GuilleminLab unveiling that mucus binding by bacteria is crucial for host-microbe symbiosis. cell.com/cell-host-microbe/f…
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Sticking point for Aeromonas. @tjarrods @GuilleminLab report #zebrafish #symbiont, Aeromonas, uses mucin-reg. adhesin to control its inflammatory character & spatial organization in gut.Analogous Akkermansia adhesins suggest similar mechanisms in human gut cell.com/cell-host-microbe/f…
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Cell-type-specific responses to the microbiota across all tissues of the larval zebrafish dlvr.it/SjPf71

Cell-type-specific responses to the microbiota across all tissues of the larval zebrafish

The Larval Zebrafish Gnotobiotic Atlas provides a comprehensive resource of microbiota-dependent transcriptomes across the entire body at single-cell resolution. Massaquoi et al. show gene expression...

cell.com
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Congratulations to @SconceMichelle and her fantastic team of co-authors on the publication of this Gnotobiotic Atlas that reveals the impacts of the microbiota on transcriptional programs across all tissues of a model vertebrate, the zebrafish: sciencedirect.com/science/ar…
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We couldn't be more excited for our Gnotobiotic Atlas to be published today! sciencedirect.com/science/ar…
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Our #SpotlightZebrafish this week is on Dr. Laura Desban @DesbanLaura a #postdoc with #EisenLab & @GuilleminLab @uoregon. She studies how interactions between microbes and chemosensory systems shape animal behavior– specifically in context of olfaction and social behavior (1/2)
An image of a 6 dpf larval zebrafish head immunostained for elav in magenta, SV2 in cyan and pERK in yellow.

ALT An image of a 6 dpf larval zebrafish head immunostained for elav in magenta, SV2 in cyan and pERK in yellow.

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For bacterial genome sequencing, would you pick fast, good, or cheap? Now you can get ALL 3 with our new ONT sequencing service that almost always produces circular, full-length bacterial chromosome contigs with consensus accuracy >Q50 -- often with their full plasmids too! (1/3)
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Thanks for this thoughtful preview
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Our paper is out today in PLOS Biology, please RT and tell us what you think! We discovered that bacteria encourage zebrafish social behavior by promoting microglial remodeling of 'social neurons'.🧵 journals.plos.org/plosbiolog… @PLOSBiology @MooreFoundation @LSRFdtn @ZebrafishRock
Symbiotic gut bacteria (yellow) promote social behavior by influencing forebrain development in zebrafish. Illustration by E. Anne Martin.

ALT Symbiotic gut bacteria (yellow) promote social behavior by influencing forebrain development in zebrafish. Illustration by E. Anne Martin.

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New! Online now: BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass dlvr.it/Sb51Ff

BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell...

Hill et al. show in zebrafish and mice that gut bacteria secrete membrane permeabilizing BefA proteins that traffic to the pancreas and stimulates insulin-producing β cell proliferation. BefA targets...

cell.com
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So pleased to see the publication of this epic story from @Jen_Suzanne, @SconceMichelle, @emmaligh, Elena Wall, Jim Remington, @RParthasarathy7, @RoundLabUtah, @MurtaughLab authors.elsevier.com/a/1fvea…
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So proud to finally share our finished work describing the membrane busting mechanism of our beloved bacterial BefA protein, out today in @Cell_Metabolism! authors.elsevier.com/a/1fvea…
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Two prominent research groups come to a shockingly similar finding from totally different angles! Checkout these two papers #OnlineNow @seeleyrj #KarenGuillemin 🔗 cell.com/cell-metabolism/ful… 🔗 cell.com/cell-metabolism/ful…
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Also, check out* this Essay in @ScienceMagazine by lead author of the BefA paper, Jennifer Hampton Hill, winner of the 2022 NOSTER & Science Microbiome Prize science.org/doi/10.1126/scie…

From bugs to β cells

Do ancient microbial irritants offer early life protection against diabetes?

science.org
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Honored to be selected as the winner of this year's Noster & Science Microbiome Prize! A huge thanks to all the support on this epic project @GuilleminLab @RoundLabUtah @MurtaughLab Go read my essay on beta-cells and microbes in @ScienceMagazine ! 🤩 science.org/doi/10.1126/scie…

From bugs to β cells

Do ancient microbial irritants offer early life protection against diabetes?

science.org
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Jennifer Hampton Hill is the winner of this year’s NOSTER & Science Microbiome Prize for her work showing that restoring lost bacterial cues in the gut can stimulate development of insulin producing cells. Learn more: fcld.ly/28z28x0
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I am so proud of @Jen_Suzanne, Grand Prize Winner of the Noster & Science Prize for this essay about her pioneering work: From bugs to β cells science.org/doi/10.1126/scie…

From bugs to β cells

Do ancient microbial irritants offer early life protection against diabetes?

science.org
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This preprint describes the vast transcriptional responses elicited by the microbiota across every cell of the developing vertebrate body: biorxiv.org/content/10.1101/…

GLOBAL HOST RESPONSES TO THE MICROBIOTA AT SINGLE CELL RESOLUTION IN GNOTOBIOTIC ZEBRAFISH

Resident microbes are a feature of vertebrate animals that influence diverse aspects of their biology from tissue development to metabolism. Here we describe transcriptional responses to the microb...

biorxiv.org
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Our work on the biochemical mechanism behind a bacterial modulator of host development is out as a preprint. Check it out to learn how both host and microbial membrane perturbing proteins promote the expansion of insulin producing beta-cells. #microbiome #BefA
bioRxiv@biorxivpreprint25 Mar 2022
A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass biorxiv.org/cgi/content/shor… #bioRxiv
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Our preprint describes how a secreted bacterial protein, BefA, disseminates through the body and stimulates pancreatic beta cell expansion via its membrane permeabilizing activity: biorxiv.org/content/10.1101/…

A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass

Microbiome dysbiosis is a feature of diabetes, but how microbial products influence insulin production is poorly understood. Here we report the mechanism of BefA, a microbiome-derived protein that...

biorxiv.org
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