Kate Jeffrey (@KateJeffrey1) header
Kate Jeffrey (@KateJeffrey1) profile picture

Kate Jeffrey

@KateJeffrey1

Immunologist. Epigeneticist. @Moderna_tx. Formerly @MGH_RI and @harvardmed @broadinstitute. Australian. Proud mother.

 Boston, MA
jeffreylab.mgh.harvard.edu
Joined April 2012
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Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)Photo by Kate Jeffrey (@KateJeffrey1)
Proud of this one. Online today @CellCellPress "Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases". @harvardmed @MGH_RI @Harvard_Imm #IBD #crohnsdisease #Epigenetics authors.elsevier.com/a/1fZ7U… cell.com/cell/fulltext/S0092…
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Come work with me at Moderna! Our Immune Therapeutics team is seeking a bold, relentless, innovative immunologist and leader at the Executive Director level to discover and deliver on the next wave of mRNA-based immune therapies. #mrna #Immunology modernatx.wd1.myworkdayjobs.…
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Explore emerging #Macrophage #Neutrophils research with field leaders @KeystoneSymp Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic, this April in Banff! keysym.us/KSInnateImmune24 #KSInnateImmune24
Image from Kate Jeffrey (@KateJeffrey1)
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Selected by editor @IforRWilliams for #DayOfImmunology, this work offered a way to identify gut viruses that drive illness in patients with #IBD—a growing public health concern in many countries. @F_Adiliaghdam @KateJeffrey1 @MGH_GI scim.ag/2qk
Image from Science Immunology (@SciImmunology)
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ICIS members watch 2022 Annual Business Meeting, win a hoodie @KingOfPathogens @slg1717 @ProfJudiAllen @jakstatman @FitzgeraldKate @LabCarpenter @KateJeffrey1 @123456789Dusan @RubyDaw26 @JustinaKulika @VangelisAndrea1 cytokinesociety.org/2022-ici… via cytokinesociety.org/2022-ici…
Image from ICIS 🦋 @cytokinesociety.bsky.social (@CytokineSociety)
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Vale, David Allis. #epigenetics #chromatin
Rockefeller University (@RockefellerUniv) profile pictureRockefeller University@RockefellerUniv9 Jan 2023
It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.
Image from Rockefeller University (@RockefellerUniv)
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Counting down the days to 2023! Today we are highlighting the use of CUTANA CUT&Tag by @KateJeffrey1 to help understand how variants in the #epigenetic reader protein SP140 impact macrophage function and Crohn's disease. Read more here: hubs.la/Q01wqQX60
Image from EpiCypher, Inc. (@epicypher)
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#Viruses contribute to intestinal homeostasis but can also provoke inflammation. Join our webinar to learn how @KateJeffrey1 @moderna_tx identifies unique enteric viruses associated with inflammatory diseases. 📆December 1 @ 11AM EST Register now: drugdiscoverynews.com/the-da…
The dark side of the gut: Probing the intestinal virome | Drug Discovery News

The dark side of the gut: Probing the intestinal virome | Drug Discovery News

Scientists uncover long overlooked players in the gut microbiota and their roles in disease pathogenesis.

drugdiscoverynews.com
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SP140 regulates #microbiota & IBD risk. @fraschillair @KateJeffrey1 show phagocytes lacking SP140 (#epigenetic reader linked to #CrohnsDisease) are unable to mount homeostatic #antibacterial responses. Pathobionts expand in mice & humans lacking SP140 cell.com/cell-host-microbe/f…
Image from Cell Host & Microbe (@cellhostmicrobe)
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Kate Jeffrey retweeted
Xavier Lab (@TheXavierLab) profile picture
Xavier Lab@TheXavierLab3 Oct 2022
New in @NatureGenet, @_kjag, @kanishkadey et al present sc-linker— a method to integrate scRNA-seq and GWAS data & identify cell-type specific disease programs! 🎉 Exciting work from the #KlarmanCellObservatory nature.com/articles/s41588-0…
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A fantastic discovery by Megha Basavappa (Jeffrey lab alum) and tour-de-force @FlyByVirus. Direct antiviral functions for a lncRNA. – at Cambridge, MA
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The innate Kates check out the big island @CytokineSociety. Congrats to all on a stellar meeting.
Image from Kate Jeffrey (@KateJeffrey1)
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#Cytokines2022 – at Cambridge, MA
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A great collaboration with @cam_phd and @SwirskiLab. Lack of #sleep promotes inflammation via #epigenetic alterations in HSPCs – at Hawaii, USA
Cameron McAlpine (@cam_phd) profile pictureCameron McAlpine@cam_phd21 Sep 2022
We are thrilled to share our latest findings on #sleep and #hematopoiesis! “Sleep exerts lasting effects on hematopoietic stem cell function and diversity” Out today in @JExpMed @IcahnMountSinai @SinaiHeartBlood @SinaiBrain rupress.org/jem/article/219/…
Sleep exerts lasting effects on hematopoietic stem cell function and diversity

Sleep exerts lasting effects on hematopoietic stem cell function and diversity

Sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells (HSPCs) and increases their proliferation, priming them for exagge

rupress.org
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New in @cellhostmicrobe we report a critical immune-centric role for #epigenetic reader SP140 in controlling the #microbiome. Humans and mice lacking SP140 displayed blooms of proteobacteria which was transmissible and a driver of #IBD cell.com/cell-host-microbe/f…
Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

A loss-of-function mutation in the chromatin reader SP140 is associated with Crohn’s disease. Fraschilla et al. demonstrate that SP140-deficient phagocytes lack the ability to mount homeostatic...

cell.com
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A stellar effort by @Harvard_Imm graduate student @fraschillair (who now embarks on her postdoc in the Tyler Jacks lab) with help from @HajeraAmatullah and Raza-Ur Rahman.
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Mutations within this epigenetic reader associate with #crohnsdisease, #MultipleSclerosis and #CLL and may constitute a predisposing event in human diseases provoked by microbiota more generally authors.elsevier.com/a/1fnZ7…
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#Epigenetic readers are often mutated in disease, but their functions remain largely unknown. @HajeraAmatullah @KateJeffrey1 study reader SP140 in #Crohnsdisease and reveal new avenues for CD research. Bonus- another great application of CUTANA™ CUT&Tag! hubs.la/Q01ltrJS0
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Kate Jeffrey retweeted
Sean P.J. Whelan (@vsv512) profile picture
Sean P.J. Whelan@vsv51230 Aug 2022
Please share this broadly. We are excited to continue to expand our community of microbiologists!
Image from Sean P.J. Whelan (@vsv512)
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Incredible work by the talented (and hard working!) @HajeraAmatullah with support from @fraschillair, @dorkeyamas and all the Jeffrey lab. Kudos to our collaborators @RiouxLab. And a public tip-of-hat to @russellevance for generously supplying Sp140 CRISPR KO mice. @NIHFunding
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Mutations within immune-restricted epigenetic reader SP140 were shown to associate with 3 #immune diseases: #crohnsdisease, #multiplesclerosis and #ChronicLymphocyticLeukemia (#CLL). However, how loss of SP140 contributes to these diseases remained elusive.
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