@SSGCID

Seattle Structural Genomics Center for Infectious Disease

ssgcid.org/
Joined April 2013
  • Tweets158
  • Following105
  • Followers222
18Media
Very excited to share RoseTTAFold All-Atom and RFdiffusion All-Atom, methods for structure prediction and design of biomolecular assemblies! biorxiv.org/content/10.1101/… 1/n
10
164
16
570
182,932
Check how we @SSGCID are helping increase #DiversityandInclusion in #STEMeducation !
Structural Biology Communications@ActaCrystF10 Oct 2023
Jon Agirre: Using structural genomics depositions in undergraduate teaching of protein crystallography: everybody wins #StructuralGenomics #InorganicPyrophosphatases #Legionella @uniofyork @biophyskrys... #IUCr scripts.iucr.org/cgi-bin/pap…
3
2
870
Another fascinating application of protein design from the Baker Lab @IPD biorxiv.org/content/10.1101/…

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation

Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by interaction with endogenous ligands. Therapeutic approaches such as LYTAC[1][1],[2][2] and KineTAC[3][3], have...

biorxiv.org
87
No offense to Coot, but dang 🩷 that button! @TerwillTom @UCSFChimeraX
96
#AlphaLink2 goes #ColabFold 😎 @sokrypton #AlphaFold  biorxiv.org/content/10.1101/… colab.research.google.com/gi…
2
40
150
19,209
Check out the latest from our colleagues at UCB and niu.edu/hagen/ ! Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor pubmed.ncbi.nlm.nih.gov/3722…

The Hagen Group – NIU – Northern Illinois University

niu.edu
2
123
After months of hallucinating one all-alpha design after another... this @UWproteindesign paper is a little gem. pnas.org/doi/10.1073/pnas.22…

De novo design of small beta barrel proteins | PNAS

Small beta barrel proteins are attractive targets for computational design because of their considerable functional diversity despite their very sm...

pnas.org
5
28
2,057
Huge congrats to the BakerLab!
Institute for Protein Design@UWproteindesign25 Jan 2023
David Baker, together with Demis Hassabis & John Jumper of @DeepMind, has received the Frontiers of Knowledge Award from @FundacionBBVA for "contributions to the use of A.I. for the accurate prediction of the 3D structure of proteins." ipd.uw.edu/2023/01/frontiers…
2
217
We’re very happy to announce that our RFdiffusion manuscript is now on bioRxiv! A lot can change in a week - we’ve now tested over a thousand designs and there’s so much exciting new data! 🧵
24
242
39
1,169
Here's to our next 5 years--SSGCID launches its 16th year! Thanks to all our collaborators for your support! See our structures to date rcsb.org/search?request=%7B%…

RCSB PDB

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and...

rcsb.org
1
What a special moment: the #COVID19 vaccine we designed with @coronalexington @KingLabIPD has met its primary endpoints in the phase 3 clinical trial run by SK bioscience!!! @HHMINEWS @UWproteindesign @UWBiochemistry 1/4 newsroom.uw.edu/news/uw-medi…

UW Medicine-developed COVID vaccine effective in test - UW Medicine | Newsroom

News and information for journalists

newsroom.uw.edu
4
50
6
175
A very small piece to understand B. mandrillaris and show that many of the current anti-parasitics are terrible drugs against this organism. More work needs to be done to develop better drugs! Thanks to Isabelle and the teams collaborative effort. rdcu.be/cANfr
1
2
15
Replying to @LindorffLarsen
Don't think I've ever seen tweets cited before 😂 #OpenTwitterScience
3
57
6
135
HUGE congratulations to David Veesler @veeslerlab hhmi.org/news/hhmi-invests-3…
1
10
Sharing our latest preprint on #SARSCoV2 B.1.617.2 (delta), B.1.617.2+ (delta+) and B.1.617.1 (kappa) variants led by @Dr_MattMcCallum 1/9 biorxiv.org/content/10.1101/…

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants

Worldwide SARS-CoV-2 transmission leads to the recurrent emergence of variants, such as the recently described B.1.617.1 (kappa), B.1.617.2 (delta) and B.1.617.2+ (delta+). The B.1.617.2 (delta)...

biorxiv.org
5
97
18
229
huddle.uwmedicine.org/audaci…
9
19
There are 366 new PDB entries this week. This #cryoEM structure of the spike protein (7n8h) from #SARSCoV2 epsilon variant with bound antibodies - part of a study into potential immune evasion by the variant, in @ScienceMagazine. Latest PDB entries: PDBe.org/latest
21
3
60
Accurate prediction of protein structures and interactions using a 3-track network biorxiv.org/content/10.1101/…

Accurate prediction of protein structures and interactions using a 3-track network

DeepMind presented remarkably accurate protein structure predictions at the CASP14 conference. We explored network architectures incorporating related ideas and obtained the best performance with a...

biorxiv.org
24
4
90
Re-inventing the stuff of life: custom-crafted proteins let @coronalexington @veeslerlab make a potent COVID vaccine, and @UWproteindesign create novel antivirals. Exquisite control over proteins could change the world, reports @sciam scientificamerican.com/artic…

Artificial Proteins Never Seen in the Natural World Are Becoming New COVID Vaccines and Medicines

Researchers have begun to crack the code of protein structure, allowing them to remake, well, everything

scientificamerican.com
1
11
1
19
Structural characterization of a monoclonal antibody that cross-reacts with eight β-coronavirus spike proteins from three viral lineages reveals a conserved cryptic epitope that could serve as target for structure-guided design of a pan-coronavirus vaccine nature.com/articles/s41594-0…

Structural basis for broad coronavirus neutralization

Nature Structural & Molecular Biology - Structural characterization of B6, a monoclonal antibody that cross-reacts with eight β-coronavirus spike proteins from three viral lineages,...

nature.com
1
3
3
Load more