@SSGCID

Seattle Structural Genomics Center for Infectious Disease

ssgcid.org/
Joined April 2013
  • Tweets158
  • Following105
  • Followers222
18Media
Very excited to share RoseTTAFold All-Atom and RFdiffusion All-Atom, methods for structure prediction and design of biomolecular assemblies! biorxiv.org/content/10.1101/… 1/n
10
164
16
570
182,933
#AlphaLink2 goes #ColabFold 😎 @sokrypton #AlphaFold  biorxiv.org/content/10.1101/… colab.research.google.com/gi…
2
40
150
19,209
We’re very happy to announce that our RFdiffusion manuscript is now on bioRxiv! A lot can change in a week - we’ve now tested over a thousand designs and there’s so much exciting new data! 🧵
24
242
39
1,169
What a special moment: the #COVID19 vaccine we designed with @coronalexington @KingLabIPD has met its primary endpoints in the phase 3 clinical trial run by SK bioscience!!! @HHMINEWS @UWproteindesign @UWBiochemistry 1/4 newsroom.uw.edu/news/uw-medi…

UW Medicine-developed COVID vaccine effective in test - UW Medicine | Newsroom

News and information for journalists

newsroom.uw.edu
4
50
6
175
A very small piece to understand B. mandrillaris and show that many of the current anti-parasitics are terrible drugs against this organism. More work needs to be done to develop better drugs! Thanks to Isabelle and the teams collaborative effort. rdcu.be/cANfr
1
2
15
Replying to @LindorffLarsen
Don't think I've ever seen tweets cited before 😂 #OpenTwitterScience
3
57
6
135
Sharing our latest preprint on #SARSCoV2 B.1.617.2 (delta), B.1.617.2+ (delta+) and B.1.617.1 (kappa) variants led by @Dr_MattMcCallum 1/9 biorxiv.org/content/10.1101/…

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants

Worldwide SARS-CoV-2 transmission leads to the recurrent emergence of variants, such as the recently described B.1.617.1 (kappa), B.1.617.2 (delta) and B.1.617.2+ (delta+). The B.1.617.2 (delta)...

biorxiv.org
5
97
18
229
huddle.uwmedicine.org/audaci…
9
19
There are 366 new PDB entries this week. This #cryoEM structure of the spike protein (7n8h) from #SARSCoV2 epsilon variant with bound antibodies - part of a study into potential immune evasion by the variant, in @ScienceMagazine. Latest PDB entries: PDBe.org/latest
21
3
60
Accurate prediction of protein structures and interactions using a 3-track network biorxiv.org/content/10.1101/…

Accurate prediction of protein structures and interactions using a 3-track network

DeepMind presented remarkably accurate protein structure predictions at the CASP14 conference. We explored network architectures incorporating related ideas and obtained the best performance with a...

biorxiv.org
24
4
90
Re-inventing the stuff of life: custom-crafted proteins let @coronalexington @veeslerlab make a potent COVID vaccine, and @UWproteindesign create novel antivirals. Exquisite control over proteins could change the world, reports @sciam scientificamerican.com/artic…

Artificial Proteins Never Seen in the Natural World Are Becoming New COVID Vaccines and Medicines

Researchers have begun to crack the code of protein structure, allowing them to remake, well, everything

scientificamerican.com
1
11
1
19
Structural characterization of a monoclonal antibody that cross-reacts with eight β-coronavirus spike proteins from three viral lineages reveals a conserved cryptic epitope that could serve as target for structure-guided design of a pan-coronavirus vaccine nature.com/articles/s41594-0…

Structural basis for broad coronavirus neutralization

Nature Structural & Molecular Biology - Structural characterization of B6, a monoclonal antibody that cross-reacts with eight β-coronavirus spike proteins from three viral lineages,...

nature.com
1
3
3
Happy to announce that our work on broadly protective nanoparticle-based influenza vaccines has been published in Nature! rdcu.be/chpnW Supraseasonal flu vaccine = protects against seasonal flu even when that year's strain prediction is off, plus some more 1/9
4
219
43
724
The University of Washington’s Institute for Protein Design has become a hub to galvanize de novo protein engineering, citizen science and much more since its founding in 2012 | ⁦@NatureBiotech⁩ nature.com/articles/s41587-0… – at Seattle, WA
17
52
Read this month's #WIPOResearch Snapshot about human African trypanosomiasis #HAT and Dr. Kande's discovery of the first all-oral treatment. #sleepingsickness bit.ly/3hgYir1
1
We are pleased to announce @SSGCID is supporting @fiocruz Dr. Stenio Fragoso’s efforts to develop a construct to express T. cruzi Topoisomerase II, a drug target for #Chagas Disease.
1
Our study of the S309 SARS-CoV-2 neutralizing antibody is featured in the @sfchronicle (thank you @CDizikes). Clinical trials are expected to start this summer! #COVID19 Based on: nature.com/articles/s41586-0… sfchronicle.com/bayarea/arti…

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

Nature - The monoclonal antibody S309, identified from memory B cells of an individual infected with SARS-CoV in 2003, or antibody cocktails that contain this antibody potently neutralize SARS-CoV-2.

nature.com
15
1
40
Really excited that our article describing the structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein is featured on the cover of @CellCellPress Cover art by @MelodyGCampbell doi.org/10.1016/j.cell.2020.…
13
69
8
283
We can learn a lot about a virus from its structure! Great working with @TheMenacheryLab @bonnieberkowitz @JohnMuyskens & @asteckelberg to discuss #SARSCoV2 and #COVID19 for @washingtonpost. Based on: sciencedirect.com/science/ar… wapo.st/coronavirus-structur…
1
24
40
Audacious Philanthropy: Congrats to David Baker and his Institute for Protein Design for winning a #TED2019 Donation of $45M for foundational science! Imagine a universal flu vaccine capable of providing lifetime immunization newsroom.uw.edu/news/protein… – at Vancouver, British Columbia
2
24
77
Load more