An implantable, wirelessly powered electronic device could offer a drug-free approach to managing the intertwined metabolic disorders of obesity and type 2 diabetes. The device uses electrocatalysis to remove excess glucose from the bloodstream on demand. Learn more in Science: scim.ag/47twScK

Researchers have developed an AI-based approach to help physicians with real-life clinical workups, starting with the patient’s chief complaint, systematically asking questions and deciding what laboratory and imaging tests to order, and then continuing the evaluation on the basis of the answers received. Learn more this week in Science: scim.ag/3U8xn94

Home decorating isn’t unique to Homo sapiens. More than 40,000 years ago, bands of Neanderthals turned a spacious rock shelter in the mountains of Spain into a cozy home, fashioning wood into tools and windbreaks and burning it for heat and light. That picture comes from a first-of-its-kind trove of Neanderthal wooden artifacts from a domestic space, found at a cliffside site called Abric Romaní, 50 kilometers west of Barcelona. Learn more: scim.ag/3VK5zZb @NewsfromScience

By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. Find out more in @ScienceTM: scim.ag/3UycT9T

Animals and plants use conceptually similar immune systems to detect microbes and activate defenses. In both lineages, pattern recognition receptors (PRRs) perceive pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) and host-derived damage-associated molecular patterns (DAMPs). Whereas animals rely on specialized immune cells, plants harness individual cells expressing diverse PRRs. In the apoplast, which lies outside the plasma membrane and includes the cell wall, PRRs detect immunogenic fragments released from microbial proteins by plant hydrolytic enzymes. Conversely, pathogen-secreted enzymes can degrade constituents of the apoplast, generating DAMPs that activate immunity. In three new Science papers, researchers report expansions of this surveillance, revealing receptor architectures and mechanisms that enable plants to discriminate immunogenic carbohydrates. The findings illustrate how ligand specificity and receptor assembly confine immune activation to the context of microbial challenge. Learn more in a new #SciencePerspective: scim.ag/4ib9BRC

Last call: Apply for the BioInnovation Institute & Science Prize for Innovation This prize recognizes bold researchers who are asking fundamental questions at the intersection of the life sciences and entrepreneurship. The Grand Prize winner will receive a cash prize of USD 25,000 and have their winning essay published in Science, in print and online. Apply by 1 November 2026: bit.ly/3TuI19S

In the latest #SciencePodcast🎙️, Contributing Correspondent Lizzie Wade dives into how archaeologists are revisiting the standard Inca chronology as radiocarbon dates mix up the timeline for the empire’s inception and growth. 🎧 Listen here: scim.ag/4jmkwKA

Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @ScienceTM scim.ag/4jpH795

How does the #glycome of gamma-delta T cells affect their activation toward an autoimmune state? Learn more in Science #Immunology about these important sugar molecules and their impact on inflammatory disease. scim.ag/47UlTJn

Does generative AI dilute markets for human-created work? In a new #SciencePolicyForum, researchers discuss how market dilution theory, which could affect AI use in science, requires conceptual clarity and empirical evidence: scim.ag/4eDnln9