@Structure_CP

Structure is a monthly publication of @CellPressNews dedicated to research at the cutting edge of #structuralbiology. Tweets are by the Editors.

 Cambridge, MA, USA
cell.com/structure/home
Joined August 2012
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Our research on #rhodopsins, which I was happy to present in Schloss Ringberg earlier this year, has been highlighted in the May issue of Structure journal. And lots of other super interesting research, too!
Structure@Structure_CP6 May 2025
Introducing Bonnie Murphy, Ville Kaila, Maxie Roessler, Volha Chukhutsina, Alisia Fadini, Sonya Hanson, Filipe Maia, and Kirill Kovalev dlvr.it/TKbj4s
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The Structural Biology and NMR Laboratory—or SBiNLab as we call it—is turning 25 🎉🧲🇩🇰 We're celebrating with a symposium on Aug. 23 that is free and open to all Great speakers incl. Ad Bax, Frauke Gräter, Harald Schwalbe, Sarah Shammas, Mikael Akke & alumni! Join us
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Our study, published in @Structure_CP, reveals how nsp16 and nsp10 assemble on SARS-CoV-2 mRNA to regulate 2'-O-methylation, a mark that evades immune restriction. Thanks to @NIH and @WelchFoundation for supporting our research on RNA modifications. sciencedirect.com/science/ar…
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The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @ScienceMagazine 🎉 You can find the full story here science.org/doi/10.1126/scie… @luminous_lab did a wonderful job on the cover and animation👩‍🎨

In-cell architecture of the mitochondrial respiratory chain

Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain,...

science.org
Science Magazine
@ScienceMagazine20 Mar 2025
In mitochondria, respiratory supercomplexes (blue) pump protons across crista membranes to create an electrochemical gradient, fueling adenosine triphosphate (ATP) synthase (pink) to regenerate ATP—the energy currency of life. Now, cryo–electron tomography captures these supercomplexes in their native organization, illuminating how the coordinated action of these molecular machines drives life’s fundamental energy conversion. Learn more this week in Science: scim.ag/3FQ6bEh
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Just find the recording of this symposium is on YouTube Cryo-EM: The Next 50 Years Symposium youtube.com/watch?v=Y6sB8aSS…

Cryo-EM: The Next 50 Years Symposium - 1 - Welcome and opening...

First session - Chair: Hongwei WangKenneth Taylor – “My first half...

youtube.com
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Great collaboration with Pontus Gourdon's lab! Through coulmn-masking of the MSA, we were able to use AlphaFold3 to model different end-states of a membrane transporter in complex with its cargo.
Structure@Structure_CP19 Mar 2025
Online now! Cryo-EM structure of the human monocarboxylate transporter 10 dlvr.it/TJdQ2s
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Structure retweeted
Llorca lab@LlorcaLab6 Mar 2025
Our take on the struture of the R2T complex 🌱 Now out in @Structure_CP! A fun collab led by @alopezperrote and the @AlabadiDavid lab at @IBMCP . Check it out in the next post 👇
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Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @mhli41 and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
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Hi, we have published a study in @Structure_CP that you may like it! This work is the result of a fantastic collaboration between our group @IBMCP and @LlorcaLab (@CNIOStopCancer), aimed at understanding the role of the HSP90 cochaperone R2T in plants doi.org/10.1016/j.str.2025.0… 👇
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🔴⚠Next CNIO-@CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥Organizers: @LlorcaLab, @rfleiro and @NogalesLab. 🔗More info and registrations: cnio.es/eventos/machines-act…
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🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes. 👥 Meet the organisers: @LlorcaLab, @rfleiro and @NogalesLab. cnio.es/eventos/machines-act…
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📣 Save the dates 📅 We are organizing a Benzon Symposium on "Protein structure prediction and design" with what I think is an amazing set of speakers Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and abstract submission will open in March
Flyer for a Benzon Symposium on Protein structure prediction and design in biology and pharmacology (Sept. 1–4, 2025). Speakers include: Gabriel Rocklin, Birte Höcker, Amy Keating, Tanja Kortemme, Bruno Correia, Sarel Fleishman, Ashutosh Chilkoti, Minkyung Baek, Noelia Ferruz, James Fraser, Alan Moses, Susan Marqusee, Ben Lehner, Mohammed AlQuraishi, Dek Woolfson, Gustav Oberdorfer, Hannah Wayment-Steele, Ora Schueler-Furman, Jenifer Listgarten, Alexander Rives, & Max Bonomi.

ALT Flyer for a Benzon Symposium on Protein structure prediction and design in biology and pharmacology (Sept. 1–4, 2025). Speakers include: Gabriel Rocklin, Birte Höcker, Amy Keating, Tanja Kortemme, Bruno Correia, Sarel Fleishman, Ashutosh Chilkoti, Minkyung Baek, Noelia Ferruz, James Fraser, Alan Moses, Susan Marqusee, Ben Lehner, Mohammed AlQuraishi, Dek Woolfson, Gustav Oberdorfer, Hannah Wayment-Steele, Ora Schueler-Furman, Jenifer Listgarten, Alexander Rives, & Max Bonomi.

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Check out @RasmusNorrild's work with Alex Buell @biophysics_dtu and @JosephRogers100 developing and using Condensate Partitioning by mRNA-Display to probe phase separation of ~100.000 sequences, and @SoBuelow simulations to support and analyse the experiments
Rasmus Krogh Norrild@RasmusNorrild21 Dec 2024
We are finally ready to share the preprint version about our use of mRNA-display to study what makes disordered proteins form condensates, at the proteome-scale! Check it out here:
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The roles of FUS-RNA binding domain and low complexity domain in RNA-dependent phase separation. Read more from @MyongLab2 & colleagues in @Structure_CP #bps2025 hubs.li/Q036KBwN0

The roles of FUS-RNA binding domain and low complexity domain in RNA-dependent phase separation

Ganser et al. investigate the molecular interactions underlying FUS phase separation in the presence of RNA, revealing distinct roles for the RBD and LCD. While RBD drives RNA recognition, multival...

cell.com
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"Nuclear pore permeability and fluid flow are modulated by its dilation state" Take a look at this study from @Beck_Laboratory, @HummerLab et al. in @MolecularCell #bps2025 hubs.li/Q036KJ3k0

Nuclear pore permeability and fluid flow are modulated by its dilation state

Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings,...

cell.com
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Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. @DKDas_lab & colleagues report in @Structure_CP #bps2025 hubs.li/Q036KNmq0
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Please check out the full paper, now in @Structure_CP! A big thanks to the authors Benjamin Lewis, Muhammad Uddin, Katie Kuo, Laila Shah, Nicola Harris, Paula Booth, @d_hammerschmid, JC Gumbart, @MultidrugEfflux, and Eamonn Reading! cell.com/structure/fulltext/…

Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump

RND multidrug efflux pumps have a critical role in innate and acquired antibiotic resistance in gram-negative bacteria. Russell Lewis et al. used a combination of hydrogen/deuterium exchange mass...

cell.com
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We are proud to announce the winners of the 5th annual Rising Black Scientists Awards! Learn more about each winner and read their essays now published in @CellCellPress: cell.com/news-do/rising-blac… Sponsored by #CellPress, @CellSignal, and @ElsFoundation
Headshots of the winners of the 5th Annual Rising Black Scientists Awards Jheannelle Johnson of Stanford and Howard University, Victor Ekuta, MD, of the Morehouse School of Medicine, Kenna Gloria Agbugba of Philander Smith University, & Nyasha Milanzi pf Michigan Technological University. Sponsored by Cell Press, Cell Signaling Technology, and the Elsevier Foundation

ALT Headshots of the winners of the 5th Annual Rising Black Scientists Awards Jheannelle Johnson of Stanford and Howard University, Victor Ekuta, MD, of the Morehouse School of Medicine, Kenna Gloria Agbugba of Philander Smith University, & Nyasha Milanzi pf Michigan Technological University. Sponsored by Cell Press, Cell Signaling Technology, and the Elsevier Foundation

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Structure retweeted
Cell@CellCellPress7 Feb 2025
The new issue is out 👉cell.com/cell/current Featuring the proteomic landscape of human preimplantation development and failure, a trans-ancestry GWAS of major depression identifying 697 associated variants, and how norepinephrine oscillations during NREM sleep drive glymphatic clearance! ⁠ This issue also features the winning essays of the rising black scientists awards. Congrats to the awardees!! 📷 Credit: Natalie Hauglund and Nadia Alzoubi.
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Cell@CellCellPress21 Jan 2025
Now online! Structural and functional analysis of the Nipah virus polymerase complex dlvr.it/THV5w4

Structural and functional analysis of the Nipah virus polymerase complex

The cryo-EM structure and mutational analysis of the Nipah virus polymerase complex identify features critical for RNA replication and transcription with the potential to aid in the development of...

cell.com
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