Optimalist | I vet new tech for VCs | TikToker new to Twitter | Tweets about evidence-based life optimization + my new Twitter+YouTube journey
NYC
Joined June 2020
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Avisha NessAiver retweeted
A review of 68 vaccine effectiveness studies:
Preserved protection vs hospitalizations and deaths out to 6 months, substantial waning vs infections, especially Omicron; similar pattern with boosters
thelancet.com/journals/lanre… @LancetRespirMed
@sbacon20 @CIUSSSnmtl @Concordia
Avisha NessAiver retweeted
Being evidence-based does not mean cherry-picking what suits your interest.
Being evidence-based requires looking at the TOTALITY of the evidence available on a topic to come to a conclusion.
Avisha NessAiver retweeted
Tim Ferriss (@tferriss) wants to airdrop 5 of you sexy munchkins a CØCKPUNCH NFT on mint day! It’s coming soon. This is the only planned public giveaway.
Just visit premint.xyz/cocks *before* 3pm EST this Wednesday, Nov 23rd. The earlier, the better. Good luck, everyone!
Avisha NessAiver retweeted
A new @Nature feature summarizing the data for Covid vaccines in kids
nature.com/articles/d41586-0…
Avisha NessAiver retweeted
👉Clinical and in vitro evidence suggests urgent reassessment of @WHO's Therapeutics and COVID-19 Living Guideline on monoclonal antibodies is needed. ➡️Out today @TheLancet from @TheCrick and @UCLHresearch, work led by @MaryYiWeiWu ::
thelancet.com/journals/lance… ... a 🧵1/n
Avisha NessAiver retweeted
Vaccine effectiveness vs BA.5 wave hospitalization in South Africa @Discovery_SA
nejm.org/doi/full/10.1056/NE…
It was 70% vs BA.1 severe disease with 2 doses.
New report compares vs BA.1/2, 2 or 3 doses
Table and conclusion below
Avisha NessAiver retweeted
Some very encouraging new data on booster durability vs Omicron severe disease out to 7 months, for age 60+
medrxiv.org/content/10.1101/…
Avisha NessAiver retweeted
This is a brilliant, short, video on how N95s work - it really helped me to understand what they actually do and that it's not simply if a particle is too small or too big. youtube.com/watch?v=vBJpvdZX…
Avisha NessAiver retweeted
1/🧵 What is #LongCOVID⁉️
A disabling malady from ongoing inflammation, autoimmunity, & potential viral reservoirs (GI, brain?)
NEW DATA: The Lungs “light up” on special MRI Scans 3 to 9 months later in patients never hospitalized for COVID.
bit.ly/344Oajp
Avisha NessAiver retweeted
1/ @CDCgov exit isolation at day 5 w/out Neg Rapid Ag Test = dangerous policy
Important New Research
We followed 260 Health Care Workers returning to work early
• ~58% Pos on Day 6 (72% if Boosted!)
• 50% w high virus load
• **Positivity 2x-3x HIGHER if Boosted**
A thread
Avisha NessAiver retweeted
Key paper from @UCSF & @czbiohub answers nose vs. throat swab rapid test question: BinaxNOW was 98% sensitive w/ nasal swab; 49% sensitive w/ throat.(Gold standard=PCR w/ Ct<30, ie, infectious.)
So def do nose, don't do throat alone, & little gain w/ both.medrxiv.org/content/10.1101/…
Avisha NessAiver retweeted
Unvaccinated People 20 Times More Likely to Die From COVID: Study AND unvaccinated people were 13 times more likely to test positive for COVID-19 than people who were fully vaccinated (so yes, vaccines reduce transmission)
medscape.com/viewarticle/962… via @medscape
Avisha NessAiver retweeted
There is increasing twitter chatter about a new SARS-CoV-2 lineage termed AY.4.2, a descendant of the Delta (B.1.167.2) variant. It carries two characteristic mutations in the spike, Y145H and A222V. It is likely to be elevated to the rank of 'Variant under Investigation'.
1/
Avisha NessAiver retweeted
Out of >183 million Americans fully vaccinated against COVID
13,775 hospitalized breakthroughs (0.008%): 69% >65 yrs
Deaths 0.002% (0.00002) from COVID (86% >65 years)
Gives evidence for vaccines massively reducing severe disease & boosting >65
cdc.gov/vaccines/covid-19/he…
Avisha NessAiver retweeted
Another week with lots of news, but here is the key takeaway: The vaccines continue to work, especially at preventing severe outcomes. While cases in lower-vaccinated states have decreased dramatically, the gap in death rates has widened. Thread on data:
xitter.gq/ashishkjha/status/1441…
Avisha NessAiver retweeted
Created an infographic against the pseudoscience being circulated regarding spike proteins.
Avisha NessAiver retweeted
I'm in a SM Covid-19 parenting group.
A mom mentioned her child had covid and asked how long her child should stay home from school.
The answers ranged from 24 hrs to 7 days.
No one replied with the correct answer.
We like to think ppl have enough info and know what to do.
Avisha NessAiver retweeted
Finally, some data from Israel on vaccine effectiveness. Before we start, a couple of comments: 1. Almost all new infections in Israel are with the delta variant. 2. We don’t believe confirmed cases count since there are complicated incentives for testings.
