@MattCheungMD

Hematologist | @Sunnybrook | Associate Professor | @uoftmedicine | #lymphoma/Value/Health Outcomes | @ICESOntario | heme calc - https://xitter.cf/t.co/a7pF4f9B9s

 Opinions my own
sunnybrook.ca/research/team/member.asp?t=10&page=172&m=334
Joined May 2017
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Where are we after 20 years of R-CHOP in DLBCL? Update from #ASH21 with the POLARIX trial demonstrating a PFS benefit with pola-R-CHP vs R-CHOP (HR 0.73; p<0.02) but no difference in OS. #lymsm
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Matthew Cheung retweeted
Yulia Lin@dryulialin17 Apr 2023
Congrats @CPSkorupski ⭐️ on this excellent 5 things to about about Preop anemia in @CMAJ! Such a great team to work with @MattCheungMD! 🙌 @LMP_UofT @UofT_DoM @Sunnybrook cmaj.ca/content/195/15/E551

Preoperative anemia in major elective surgery

cmaj.ca
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Lisa Hicks@LisaHicksMD30 Dec 2022
Congratulations team on this important contribution to our understanding of COVID in pts with cancer. Led by rising star @igong26 . Bottom line: COVID outcomes worse in hem cancer and any on chemo. Booster shots help. @MattCheungMD @abivije @NicoleKuderer
JAMA Oncology@JAMAOnc29 Dec 2022
Vaccinated cancer pts had higher risk of breakthrough COVID-19 infection & poor outcomes incl. hospitalization & death, compared to controls without cancer, especially for those w/hematologic cancer or on active chemo. Third vaccine dose reduced this risk. ja.ma/3GqObhN
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JAMA Oncology@JAMAOnc29 Dec 2022
Vaccinated cancer pts had higher risk of breakthrough COVID-19 infection & poor outcomes incl. hospitalization & death, compared to controls without cancer, especially for those w/hematologic cancer or on active chemo. Third vaccine dose reduced this risk. ja.ma/3GqObhN
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JAMC@JAMC_CMAJ17 Oct 2022
Carence en vitamine B12 : Les patients peuvent parfois présenter des symptômes neuropsychiatriques; examiner l’alimentation et la médication est important — cmaj.ca/lookup/doi/10.1503/c… @WKSilverstein @dryulialin @MattCheungMD
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Replying to @SinaiHealth
@SinaiHealth/@UHN Geriatrician, Dr. Shabbir Alibhai as well as @abivije @ancaprica @mattcheungmd et al. released a new study which explores #frailty in patients with newly diagnosed Diffuse Large B-Cell #Lymphoma receiving curative-intent therapy. To read: bit.ly/3NtG9Fh
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CMAJ@CMAJ22 Jun 2022
Vitamin B12 is necessary for normal bone marrow and central nervous system function. B12 deficiency can cause fatigue and pallor. Here are 5 things to know: cmaj.ca/lookup/doi/10.1503/c… @WKSilverstein @dryulialin @MattCheungMD
Authors of the Five Things to Know article on Vitamin B12 deficiency note that “The incidence of vitamin B12 deficiency increases with age, affecting 5% of adults older than 60 years.”

ALT Authors of the Five Things to Know article on Vitamin B12 deficiency note that “The incidence of vitamin B12 deficiency increases with age, affecting 5% of adults older than 60 years.”

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Vitamin B12 deficiency is common and presents diversely. This article in @CMAJ describes diagnostic criteria for vitamin B12 deficiency, common etiologies of vitamin B12 deficiency, and evidence-based strategies to treat vitamin B12 deficiency. cmaj.ca/content/194/24/E843
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Journal of the @NCCN@JNCCN17 Jun 2022
𝐉𝐮𝐬𝐭 𝐏𝐮𝐛𝐥𝐢𝐬𝐡𝐞𝐝: #Frailty in Patients With Newly Diagnosed Diffuse Large B-Cell #Lymphoma Receiving Curative-Intent Therapy: A Population-Based Study: buff.ly/39z7Z4Y @abivije @ancaprica @mattcheungmd @pmcancercentre #DLBCL #lymsm
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New from @COVIDSciOntario - treatment of COVID-19 with updated guidance for mildly ill patients: NEW section on #paxlovid and REVISED section #remdesivir. covid19-sciencetable.ca/scie…
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As we’re about to get access to Paxlovid….remember it’s co-administered with ritonavir for PI-boosting. With heme malignancy drugs, be aware of its CYP3A4 inhibition and use cautiously with venetoclax, ibrutinib, TKIs, anticoagulants, etc. #lymsm
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News today of shortages of life-saving Covid drugs & HC approval of paxlovid (which will initially be in v short supply too). As a methodologist & a clinician, I wonder… how do you follow evidence-based guidance on drugs when you don’t have any drugs? 🧵 thestar.com/news/gta/2022/01…

‘Uniquely awful’: Ontario hospitals face shortages of critical drugs to treat COVID patients

As drug shortages have escalated, at least one Toronto hospital put in a lottery system to determine which patients will receive a dose of a medication.

thestar.com
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As of today, It is illegal to intimidate doctors It is illegal to intimidate nurses It is illegal to intimidate patients, It is illegal to obstruct them from providing care or receiving it. This law was passed unanimously in the House of Commons, and it comes into force today.
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Always learn so much from Alison Moskowitz - editorial on precision approach to T cell lymphomas ascopubs.org/doi/full/10.120… #lymsm
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Congrats to @igong26 @abivije @LisaHicksMD for this extensive summary of COVID vaccine seroresponses and relative benefit (compared to control) in persons with heme malignancies. #lymsm onlinelibrary.wiley.com/doi/…
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Graham Collins@graham74GC13 Jan 2022
Really important data suggesting we should be COVID vaccinating patient prior to anti-CD20 based therapies.
Toby A. Eyre@tobyeyre8213 Jan 2022
CD20-Targeted Therapy Ablates De Novo Antibody Response to Vaccination but Spares Pre-Established Immunity bloodcancerdiscov.aacrjourna…

CD20-Targeted Therapy Ablates De Novo Antibody Response to Vaccination but Spares Preestablished...

In patients with B-cell lymphoma, neutralizing antibody responses to COVID-19 vaccination after recent anti-CD20 treatment are absent but tend to endure in those who receive anti-CD20 after vaccina...

aacrjournals.org
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Matthew Cheung retweeted
Inna Gong@igong2610 Jan 2022
Happy to share our study aggregating COVID19 vaccine response in heme cancer. Thank you @abivije @MattCheungMD @LisaHicksMD and Stephen Betschel! Bottom line: lymphoid cancers, esp recent anti-CD20 Tx dramatically lower response onlinelibrary.wiley.com/doi/…
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CAR-T in 2L DLBCL - differences in study designs/populations likely explain different outcomes. Thanks to @mana1981 for help with the slide #lymsm #ASH21
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Updated guidance from our CPG guideline panel @COVIDSciOntario - evidence and ethically based, multistakeholder, reflective of current supply challenges. LOTS of new stuff for mildly ill & outpatients: #fluvoxamine #budesonide #sotrovimab #remdesivir covid19-sciencetable.ca/scie…
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Matthew Cheung retweeted
Gerald Butts@gmbutts24 Dec 2021
Thank you to all the health care workers — who won’t have much of a Christmas this year. Bless you all. 🎄 – at Ottawa, Ontario
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