@TheDynamicTim

New Ventures @ForesiteLabs applying emerging technology to biotech and therapeutics. Former @NSFGRFP fellow studying cancer & signaling dynamics @JohnsHopkins

 Baltimore, MD
Joined March 2015
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1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/scie… 🦠🧬🛠️🖥️💥

Toward life with a 19–amino acid alphabet through generative artificial intelligence design

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational...

science.org
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Tim Aikin retweeted
Jason Sheltzer@JSheltzerApr 28
Thrilled to share my lab’s new preprint describing our discovery of the E2 ubiquitin conjugating enzyme UBE2H as a widely-shared dependency in aneuploid cancer cells. @biorxivpreprint @biorxiv_cancer
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Tim Aikin retweeted
Sam Peng
@CTSPengApr 28
Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/S0092…
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Replying to @tejalpatwardhan @MilesKWang
Would have saved me so much time at the bench, very cool
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New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tom_golde 🙌 @IBECBarcelona biorxiv.org/content/10.1101/…
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❄️Time-deterministic cryo-optical microscopy, developed by researchers at @UOsaka_en, Janelia & collaborating institutions, rapidly freezes live cells under an optical microscope, capturing a snapshot of cellular activity in high resolution.
The University of Osaka@UOsaka_en25 Aug 2025
[Research] Freeze-framing the cellular world to capture a fleeting moment of cellular activity dlvr.it/TMgKNV #UOsaka #research

Freeze-framing the cellular world to capture a fleeting moment of cellular activity

resou.osaka-u.ac.jp
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I'm often asked how human genetics can be used to validate drug targets. In our new @NatureCVR paper, we provide an end-to-end framework for IL-6 inhibition🧵 👉build a genetic proxy 👉demonstrate potential for cardiovascular benefit 👉assess expected & unexpected safety signals
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3D cross-sectional views of the dynamics of chromosomes (H2B, blue) and the endoplasmic reticulum (orange) in interphase and mitotic LLC-PK1 cells over a 50 x 180 um field at 6 sec intervals, as seen in the lattice light sheet structured illumination mode of MOSAIC.
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What does pushing the boundaries of model capacity and data scale do for generative protein language models? I’m super excited to share our latest work @ProfluentBio where we begin to explore and test some of our hypotheses!
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