Marcus Siems (@itSiemsThatWay) header
Marcus Siems (@itSiemsThatWay) profile picture

Neuroscientist - attention - decision-making - large-scale interactions

Hamburg, Deutschland
Joined January 2017
Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)Photo by Marcus Siems (@itSiemsThatWay)
Marcus Siems retweeted
1/ We discovered something totally unexpected about the neural structure of consciousness that overturns decades of thinking on its biological basis and brings us significantly closer to the recipe for generating conscious awareness. New preprint: biorxiv.org/content/10.64898… (led by @HesseJanis, with @FrankLanfranchi, @_conor_mcgrory, @Yuelin_Shi, and @EngelTatiana)
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Neuronal power spectra can be described by 3 parameters: intercept, oscillations & aperiodic slope. Intercept (tDCS) & oscillations (tACS) have been modulated with non-invasive electrical stimulation - but what happens when you try modulate the aperiodic slope?
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Marcus Siems retweeted
The most important briefings of the day. Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids.
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Thanks to everyone sharing in this moment! I’m so grateful to my trainees & collaborators… dlab.stanford.edu/group-memb… (pic: optogenetics conference chairs, Tuscany) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections
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My lab’s microbial-opsin work (and by far most of the field also) is pure basic science, but it was intriguing to review the community's clinical progress– both direct translation as in retinal degeneration, and indirect translation not involving gene therapy– with a wonderful and broad international team of co-authors… nature.com/articles/s41593-0… & to adapt a long-ago figure from PMID:28912215 (2017) on the inner workings of light-gated ion channels with my long-time collaborator Peter Hegemann; photo is a memory from that year.
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Marcus Siems retweeted
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Marcus Siems retweeted
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s41596-026-0… Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @NatureProtocols ⤵️
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Marcus Siems retweeted
The New York Times ha finalizado su lista de las mejores series del siglo. Breaking Bad tomó el primer puesto.
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The ITRUSST Practical Guide on Transcranial Ultrasonic Stimulation (TUS) for neuromodulation is finally out, endorsed by the International Federation of Clinical Neurophysiology (IFCN). This is quite the “opus magnum” with 23 beautiful educational figures. buff.ly/40WtIvy
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Large-scale neural activity data across wakefulness, sleep, and anesthesia are now open. Includes EEG/EMG, brain states, Ca²⁺ traces, and spikes. Please download and play with the data! Cell Reports: doi.org/10.1016/j.celrep.202… Scientific Data: doi.org/10.1038/s41597-026-0…
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Marcus Siems retweeted
New paper! Decision-making isn't just picking winners via more neural firing, the brain reorganizing activity patterns into different subspaces, shifting from "one option vs. another" to "chosen vs. rejected" doi.org/10.1016/j.isci.2026.… #neuroscience @MIT_Picower @mitbrainandcog
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Marcus Siems retweeted
🌍🧠 OHBM 2029 is headed to Rotterdam! Mark your calendars for June 24–28, 2029 Discover the story behind OHBM 2029, from the meeting logo to why Rotterdam is the perfect host city. 👉 Read the blog: ohbm-com.com/blog/ohbm-2029-…
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Marcus Siems retweeted
🚨 8 months later, this paper found its home at @ScienceMagazine. We came up with a generative brain network model based on game theory and found that the human brain is suboptimal both in terms of wiring cost and communication efficiency. Here's why: science.org/doi/10.1126/scia…
🚨first postdoc preprint alert 🚨 We use game theory and reservoir computing to show the brain is not optimally wired for communication or wiring economy because of a third pressure in the trade-off: computational reliability. biorxiv.org/content/10.64898…
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Marcus Siems retweeted
The prefrontal cortex sends a theta rhythm signal down to visual cortex to boost relevant stimulus. Suppression of irrelevant stimuli happens visual cortex using its own rhythms to gate when those neurons are allowed to fire. biorxiv.org/content/10.64898… #neuroscience
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Marcus Siems retweeted
We have 15 open positions at Astera Neuro! We're hiring experimental and computational neuroscientists and engineers to build a large-scale research effort aimed at understanding consciousness = the brain's internal model of world and self. astera.org/careers/#box=neur… We're looking for: • Experimental Neuroscientists • Computational Neuroscientists • Optical Engineers • Hardware Engineers • Software Engineers • Probe Engineers • and more! I'll share much more about our scientific vision soon. For now: I know we could never have built this in academia. The confluence of talent across different domains, the purposive design of the org structure and open science approach, and the deep, long-term support, all aimed at cracking the brain's internal model, is unprecedented. If you want to understand consciousness, if you sense a huge gap between our internal experience of the world and our scientific understanding of it, if you believe systems neuroscience needs a fundamentally different, collaborative, and scaled up approach, we are building the ideal research environment for you. I've never been more excited in my life. Across Astera Neuro, Astera AI, and Astera Simplex, we're creating a whole new discipline around one question: how does the brain build a world model: a symbolic system that perceives the real world from flickering sensory input streams and can think, plan, and experience? Everyone here is converging on this question from a different direction. The degree of conceptual focus combined with tactical breadth is thrilling. If this sounds like you, come join us. astera.org/careers/#box=neur…
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