Richard Kollen retweeted
Good time to break the news on our big ESMO story from our Phase 1/2 trial of ISM6331 a Pan-TEAD inhibitor designed using generative AI with maximum multiparameter optimization for safety and efficacy in mind. So far, the results are very impressive and promising. I must be compliant in terms of what I say as it is highly investigational and early but please do read the approved press release and watch the ESMO Recap. The only thing I will say here is that this molecule was designed to work in a broad spectrum of biological conditions beyond cancer and TEAD has a role in aging. Kudos to the team and let's hope that the trial continues to progress nicely!
biospace.com/press-releases/…
Richard Kollen retweeted
🧬 What computational biology packages would you love to see available in another programming language?
We developed BioBabel, an AI-agent framework that autonomously reconstructs scientific software across languages (R to Python, Python to C++, Python to Rust, and beyond), dramatically accelerate the computation, preserving functionality and making tools accessible to AI agents.
We’ve already translated ~20 packages, including:
🔹 Sequencing analysis: UMI-tools (UMI processing, Python → C++).
🔹 Graphics infrastructure: grid (graphics engine), scales (data transformations), gtable (plot layouts).
🔹 Visualization: ggplot2 (grammar of graphics), ComplexHeatmap/pheatmap (heatmaps), patchwork (plot composition), ggrepel (label placement), ggalluvial (flow diagrams), ggnewscale (multiple color scales), ggh4x (advanced facets).
🔹 Single-cell analysis: Monocle 2/3 (trajectory inference), tradeSeq (trajectory-based differential expression), NicheNet (cell–cell communication), CopyKAT (copy-number alterations), DDRTree (trajectory learning).
We’re now building an open BioBabel community and would love your suggestions! SpatialCellChat from Dr. Suoqin Jin's lab (developer of CellChat) is also included as a community contribution which may also support his lab's publication. ggtracks is another from our lab that allows native genomic track visualization in Python.
Have a favorite package you’d like us to translate? Or want to collaborate on bringing your own package to another language?
Our only requests are that the translated version be featured on the Bio-Babel Community page as a community collaboration, with full credit to your lab for the original methods, and that it be recognized as a Bio-Babel community contribution. The release timing would of course be coordinated with you.
See our community page here: biobabel.stanford.edu/commun…
Richard Kollen retweeted
I captured this video in my lab to show the power of medicines called T-cell engagers.
Left: T cells move in and out of a cancer tumoroid, largely ignoring it.
Right: Add a T-cell engager, and the T cells attack. Once they recognize their targets, they tear through the tumor.
Richard Kollen retweeted
And many thanks for support from @BiswasFamilyFdn, @10xGenomics @ChanZuckerberg via 100M Cells Challenge, @broadinstitute BroadIgnite, and many more collaborators @kochinstitute @MIT @broadinstitute @MIT_IMES @ragoninstitute @mit_hst @harvardmed @ChemistryMIT @wyssinstitute(13/n)
Richard Kollen retweeted
Demystifying Topical Hemostatic Agents: A Mental Model for Surgeons
The scrub tech holds up two boxes, “SURGICEL or EVARREST?”, and you realize nobody ever taught you the difference! Today @georgoff @Kniery_Bird @mcclellanjm @nickteman break down topical hemostatic agents, one of the most used and least taught tools in the OR. You’ll get a simple two-question model for picking the right product: can your patient make their own clot, and can a patch reach the bleeding? Through trauma, vascular, and cardiac cases, the team covers when these agents earn their keep and when two minutes of pressure (no peeking!) will do the job. Bottom line: hemostatic agents speed up hemostasis, but they’re a targeted adjunct to good surgical technique, not a substitute for it.
🎧 📺 behindtheknife.org/podcast/d…
Richard Kollen retweeted
A reminder that the Trump administration canceled a contract for an mRNA H5N1 vaccine in favor of pursuing an older technology that is not likely to work. Explanatory articles from the late, missed Helen Branswell: statnews.com/2025/08/11/mrna… and statnews.com/2025/05/03/nih-…
There is something really concerning (and disappointing) going on in the US right now.
A dangerous and preventable situation.
Let me explain.
nextstrain.org/avian-flu/h5n…
1/
Richard Kollen retweeted
Most people assume that bringing down blood sugar after a meal takes a real workout, something like a brisk half hour or a trip to the gym. The research says the amount of movement needed is far smaller than that, and when you move matters even more than how long.
The reason sits in your muscles. When a muscle contracts, it pulls sugar out of the blood without needing insulin to open the door. The protein that carries the sugar in, called GLUT4, rises to the surface of the muscle cell in response to two separate signals, and muscle contraction is one of them. That is why movement lowers blood sugar even in people whose insulin works poorly, and why the effect shows up within minutes instead of after weeks of training.
A 2026 trial tested how little movement it takes. Thirty adults came in on two evenings and drank a standard sugar drink with 75 grams of glucose. On one evening they stayed seated, and on the other they stepped up and down stairs for a single minute at whatever pace felt comfortable. They rated the effort 1.9 out of 10, barely more than sitting. In the hour after the drink, their blood sugar rose about 42 percent less after the minute of stairs than after sitting, and their total sugar exposure across the session was lower too. The researchers chose the evening on purpose, because the same amount of sugar pushes blood sugar higher at night than it does in the morning.
One minute is right at the edge of what works, and it does not work in every situation. The same research group ran the comparison in the morning with bouts of 1, 3 and 10 minutes after the sugar drink. Three and ten minutes lowered blood sugar, while one minute did not come close to making a difference. When they repeated it after a real mixed meal of 650 calories, one minute did help, trimming the blood sugar rise by about 14 points on a standard glucose meter. So a single minute seems to be enough after a normal meal and in the evening, but not reliably after a morning sugar drink. Three minutes worked in every version they tested, which makes three the safer number to aim for.
Timing turned out to matter more than length. A 2023 analysis pooled eight trials with 116 people, about 4 in 10 of whom had type 2 diabetes, and compared exercising before a meal, after a meal, and not at all. Moving after the meal beat moving before it and beat doing nothing. Moving before the meal worked no better than sitting still. The analysis also found that the shorter the gap between finishing the meal and starting to move, the bigger the benefit, so a short walk taken right away does more than a longer one taken an hour later.
The useful change is in the ten minutes after you finish eating. Sitting down is what most of us do by default, and for blood sugar it is one of the weakest choices available. Climb the stairs if you have them or take a walk if you do not, and keep in mind that starting sooner matters more than going longer.
References
Morales et al., Experimental Physiology, 2026
Moore et al., Journal of Exercise Science and Fitness, 2024
Kressler et al., Nutrition, Metabolism and Cardiovascular Diseases, 2022
Engeroff et al., Sports Medicine, 2023
Beautiful video, thank you.
How does the mitotic spindle adapt to genomes that differ in size by more than 10,000-fold? Our new paper in @NatureCellBio reveals a simple scaling law and the physics behind it: chromosome crowding! 🧵
nature.com/articles/s41556-0…
Richard Kollen retweeted
There is only one thing worse than reading from your slides;
That is reading from #AI generated slides #cmgsays
And yes, I used AI to generate the image mocking people who use AI.
The irony was entirely human-generated.
The image is artificial. Unfortunately, the boredom is real.
#cmgsays
🤖 Made with AI
Richard Kollen retweeted
Replying to @DeannaIndiana
He truly is the GOAT and he also won a real Noble Peace Prize.
Richard Kollen retweeted
We're bringing back design-a-protein.com!
Fun story about this website. For our previous protein design competition, we launched it with a cheap and fast protein design pipeline, definitely not state of the art, mostly for educational purposes and to get more people interested in the field.
We had pretty low hopes that any of the designs would work, but after synthesizing and testing a few of these vibe-designed proteins in our lab, we found out that one of them actually worked! And it ended up placing #46 in the competition.
So, someone with very limited prior biology knowledge saw our launch post, opened the website, clicked a few buttons, generated a protein never seen in nature, and that protein actually performed its intended biological function when synthesized and tested in our lab.
One year later, we have a much better option available with the newly released RFD4-Proteina model, which remains as cheap and fast to run, but is much closer to state of the art than our previous pipeline. How many binders can the anon vibe designers create this time?
To me, this is one of the clearest examples of how quickly the barriers to drug discovery are falling. And when you combine increasingly accessible and powerful protein design tools with the ability to get your designs synthesized and tested without owning a lab, which is exactly what we're doing at Adaptyv, I think we're going to see tens of thousands of new drug discovery companies emerge.
Much like AWS enabled a whole generation of internet startups, I think making biology this accessible will unlock an enormous amount of innovation, hopefully leading to entirely new ways to treat diseases. This is the future we're building towards at Adaptyv.
We built a website to make it super easy to get started with protein design and participate in the Anthropic x Adaptyv protein design competition
▶️ design-a-protein.com
This week, we're challenging people to design an Ozempic-like drug. You can get started in just a few clicks, using the newly released RFD4 model to design proteins targeting the GLP-1 receptor.
We'll synthesize and test 1000+ of these designs in our automated biology lab, including whether they actually activate the cell receptor, and make all the results publicly available
Richard Kollen retweeted
Nutrient absorption in the GI tract
rt: Dr David Reiner #nutrition #TIC2026
Richard Kollen retweeted
This is how it’s done! ✊ Howard Buffet, who is the son of the Omaha Oracle Billionaire Warren Buffet, has just donated $1.4 billion to Ukraine.🇺🇦
Richard Kollen retweeted
I’m entirely with you on this.
Retsef Levi’s invocation of “violent defamation” is an extraordinary distortion of what is happening here.
A CDC facility was the target of actual violence. Meanwhile, scientists who challenge the conduct, competence, and evidence standards of a federal vaccine advisory committee are accused of belonging to a “cult.”
Dr. Daskalakis raised legitimate questions about scientific rigor, evidence grading, and transparency. Those questions deserve substantive answers.
And Angie is right about something larger: vaccine misinformation is not a harmless intellectual exercise. When it influences public health decisions, the consequences can be measured in preventable illness and death.
Disagreement is not defamation. Accountability is not persecution. And invoking the language of violence to dismiss scientific criticism is particularly offensive in the shadow of an actual attack on public health workers.
If Levi believes his committee’s decisions are scientifically defensible, he should defend the science.
That would be a far more compelling way to rest his case.
Richard Kollen retweeted
Weaponizing tragedies? You DIDN’T condemn a terrorist attack on a federal agency. You lie about vaccines. When people believe your lies, they could die. Preventable death is both lame & violent. If anyone is engaging in “violent and lame defamation” it’s you


































