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The excellent outcome of #INPST-based collaborative work
#NaturalProducts #DrugDiscovery
By: @_INPST @_atanas_ @univienna @LBG_research @FrancescaGiamp5 @Bio_Lab_UNIVPM @DHPSP @maciejbanach @ilkay_E_ORHAN @BgSciencesBAS @docmmiller @UNI_FIRENZE @NatRevDrugDisc @MedUni_Wien
Natural products in drug discovery: advances and opportunities - a new review published today from @_INPST go.nature.com/2YmK1kb @_atanas_ Readcube version rdcu.be/cem6r
International Natural Product Sciences Taskforce retweeted
“A multimodal sleep foundation model for disease prediction.” Published January 06, 2026, Nature Medicine. nature.com/articles/s41591-0…
International Natural Product Sciences Taskforce retweeted
What if your pill could confirm you swallowed it? 💊
Medication non-adherence costs the US over $100 billion and contributes to 125,000 preventable deaths annually. [1]
In 2026, MIT researchers unveiled biodegradable smart pills that signal ingestion. A separate HIV prevention study tested digital pills with 15 participants. [1][2] 🔬
The opportunity? Better adherence insights, fewer avoidable costs, and more personalized care.
But monitoring isn't the same as improving outcomes. Privacy, affordability, and patient consent remain critical.
Healthcare leaders must prove clinical value before scaling.
🤔 Where should we draw the line between smarter medication monitoring and patient surveillance?
[1] [nature.com/articles/s41467-0…](nature.com/articles/s41467-0…)
[2] [frontiersin.org/journals/psy…](frontiersin.org/journals/psy…)
#SmartPills #DigitalHealth #MedTech #PatientSafety
International Natural Product Sciences Taskforce retweeted
Advances in cancer research are driving more personalized approaches to diagnosis, treatment, and ongoing monitoring. From smarter blood testing to targeted radiotherapy, these innovations highlight the importance of precision medicine in improving treatment decisions.
From smarter blood testing and personalized lung cancer treatment to data-driven prostate cancer surveillance, expanded glioma care and targeted radiotherapy for liver cancer, Mayo Clinic is advancing new strategies in cancer care.
mayocl.in/4yZYnqx
#CancerResearch #CancerCare
International Natural Product Sciences Taskforce retweeted
Kynurenine Pathway/ IDO/ Sirt1/ NAD+/ Astrocytes/ Neurons
we have shown for the first time, that competitive inhibition of IDO and QPRT, in both astrocytes and neurons results in a dose-dependent decrease in intracellular NAD+, highlighting the essential role of the KP in NAD+ production in human brain cells. KP inhibition leads to a decrease in NAD+ synthesis and a dose dependent increase in extracellular LDH activity indicating reduced cell viability and increased cell death. Importantly, while IDO and QPRT activites appear to be inhibited equally in both astrocytes and neurons, intracellular NAD+ levels and cell viability are significantly higher in astrocytes than neurons, suggesting that changes in KP metabolism have a greater effect on the neuronal population compared to glial cells.
As NAD+ serves as a substrate for SIRT1 activity, we have also shown herein that inhibition of KP metabolism can lead to a significant decline in SIRT1 activity in the astrocytes and neurons.
Effects of Kynurenine Pathway Inhibition on NAD+ Metabolism and Cell Viability in Human Primary Astrocytes and Neurons - Nady Braidy, Gilles J. Guillemin, Ross Grant, 2011 share.google/Wg985YTeiP2Xur9…
International Natural Product Sciences Taskforce retweeted
This research highlights AI's emerging potential to identify health-related signals from facial images. However, clinical validation, fairness, and patient privacy are essential before using such tools for cancer prognosis.
#healthcare #digitalhealth
Can a single face photo help predict cancer survival?
New study @LancetDigitalH suggest that facial features encode both physiological ageing and imminent mortality risk, showing that consumer-grade photographs carry multiple physiological #health signals.
An #AI foundation model was trained on more than 40 million face images, including photos of people with cancer.
Among about 38,000 #cancer patients, those whose faces looked at least five years older than their actual age had a 21% higher risk of death, after adjusting for age, sex and cancer type.
Of patients whose estimated biological #age was more than 20 years above their real age, 21% died within 90 days. The model focused mainly on the area below the eyes and around the nose.
thelancet.com/journals/landi…
International Natural Product Sciences Taskforce retweeted
Comparative efficacy and safety of hybrid versus conventional endoscopic submucosal dissection for non-ampullary #duodenal submucosal #tumors #some4surgery link.springer.com/article/10…
International Natural Product Sciences Taskforce retweeted
When to Use Optimistic vs Pessimistic Locking medium.com/womenintechnology…
International Natural Product Sciences Taskforce retweeted
📢Last call! This is the final week to nominate for 2026 #UNIATF Awards. Nominations close on Saturday, 31 October 2026.
Do you know a ministry, city or organization making a real difference in preventing and managing 🫁 chronic #respiratory diseases while tackling the health impacts of #airpollution?
The @WHO World Health Organization and the UN Inter-Agency Task Force on NCDs #UNIATF want to hear about inspiring examples of action, innovation and cross-sector collaboration.
This year’s awards spotlight organizations that are:
🌱 Driving sustainable policy solutions
🤝 Bringing health, environment, transport, energy and urban planning together
💡Demonstrating innovative approaches and measurable impact
⚖️ Addressing health inequities and supporting marginalized communities
🚀 Mobilizing partnerships and resources for lasting change
Awards will be presented in three categories:
✅Ministries of Health and government #health agencies
✅Non-health government bodies, including #city authorities
✅NGOs, research institutions and foundations
Don’t miss your chance. Nominate them before Saturday!
Deadline: 31 October 2026. Submit nominations to [email protected]
Winners will be announced at the 80th World Health Assembly in May 2027.
Let’s celebrate the people and organizations turning bold commitments into healthier, cleaner and more equitable communities.
Nominate here uniatf.who.int/about-us/news…
International Natural Product Sciences Taskforce retweeted
AI-based facial analysis may offer new ways to explore health-related signals, including biological ageing and cancer prognosis.
Can a single face photo help predict cancer survival?
New study @LancetDigitalH suggest that facial features encode both physiological ageing and imminent mortality risk, showing that consumer-grade photographs carry multiple physiological #health signals.
An #AI foundation model was trained on more than 40 million face images, including photos of people with cancer.
Among about 38,000 #cancer patients, those whose faces looked at least five years older than their actual age had a 21% higher risk of death, after adjusting for age, sex and cancer type.
Of patients whose estimated biological #age was more than 20 years above their real age, 21% died within 90 days. The model focused mainly on the area below the eyes and around the nose.
thelancet.com/journals/landi…
International Natural Product Sciences Taskforce retweeted
Why Low Testosterone Isn’t Just About Getting Older: New U.S. Army Findings Point to Belly Fat
Key Points:
▶️ Age was not associated w/a steady decline in testosterone.
▶️ Gold-standard body fat measurements (DXA scan) more strongly explained changes in testosterone.
▶️ Waist size, an accessible & practical measurement, captured testosterone levels just as well as DXA.
▶️ Maintaining testosterone levels w/age may support a longer life in good health.
nad.com/news/why-low-testost… @chidambara09 @FarmerJeff252 @_atanas_ @Mangan150
International Natural Product Sciences Taskforce retweeted
The use of biological age and artificial intelligence in health care | @Nature_NPJ
nature.com/articles/s41514-0…
International Natural Product Sciences Taskforce retweeted
Is “moderate” #alcohol drinking really safe? A new analysis in the Journal of Studies on Alcohol and Drugs confirms it is not.
Drinking an average of 14 drinks a week (two a day) was associated with a 1 in 25 lifetime risk of dying from 🍺 alcohol-related causes. At around seven drinks a week, the risk was about 1 in 1,000. It rose sharply above one drink a day, for both men and women.
The researchers found no protective effect of #alcohol at low levels. Even about one drink a day was linked to higher risk of death from #cirrhosis, oral and oesophageal cancer.
These are population-level estimates, not individual predictions.
doi.org/10.15288/jsad.25-004…
International Natural Product Sciences Taskforce retweeted
Your scale can look fine while hidden belly fat nearly triples later dementia risk.
-
Normal BMI is not protective. Two people with the same BMI can carry very different amounts of visceral fat. (multiple observational studies)
• Waist ≥35" (women) or ≥40" (men) predicts heart disease and death better than BMI
• High midlife visceral fat linked to ~3× higher later dementia risk
• Women with elevated levels face a 37% higher risk of asthma
• Liposuction only removes pinchable fat. (It leaves the active visceral fat untouched)
This week, do this:
1. Measure your waist (not just the scale)
2. If you’re ≥35" (women) or ≥40" (men), prioritize reducing visceral fat
3. Focus on diet, strength training, and sleep before chasing more procedures
What actually moves the needle for you: waist measurement, strength training, or something else?
International Natural Product Sciences Taskforce retweeted
Get well soon. Take care. – at San Diego, CA
Ended up in the ER today after being badly injured. Got the CTs done and hoping we are all clear! 🙏 looks like im discharged today
I ended up having the best experience because the doctors in South bay are so kind and the nurses are angels.
And my amazing friend for driving from SF to Mountain View at 3 AM just to be there for me till 8 AM
International Natural Product Sciences Taskforce retweeted
Madrid 2026.
Barcelona 2027.
Milan 2028.
The journey continues.
New science, shared knowledge, lasting friendships.
One goal: better and fairer cancer care for every patient.
@myESMO @OncoAlert @OpenMedicineHQ #ESMO26 @FAndreMD @FLordick28391
International Natural Product Sciences Taskforce retweeted
One night of clinical sleep recordings helped AI predict future dementia risk
xitter.cf/_atanas_/status/211470…
International Natural Product Sciences Taskforce retweeted
AI predicted risks for 130 health conditions from one night of clinical sleep recordings.
Can a single face photo help predict cancer survival?
New study @LancetDigitalH suggest that facial features encode both physiological ageing and imminent mortality risk, showing that consumer-grade photographs carry multiple physiological #health signals.
An #AI foundation model was trained on more than 40 million face images, including photos of people with cancer.
Among about 38,000 #cancer patients, those whose faces looked at least five years older than their actual age had a 21% higher risk of death, after adjusting for age, sex and cancer type.
Of patients whose estimated biological #age was more than 20 years above their real age, 21% died within 90 days. The model focused mainly on the area below the eyes and around the nose.
thelancet.com/journals/landi…
International Natural Product Sciences Taskforce retweeted
“Saturation of moral language predicts lower content engagement on social media.” Published September 02, 2026, Nature Human Behaviour. Nature Human Behaviour
nature.com/articles/s41562-0…
International Natural Product Sciences Taskforce retweeted
Cocoa flavanols protect endothelial function during prolonged sitting in healthy older adults
▶️ Cocoa flavonols prevent the impairment of endothelial function induced by sitting for 2 hours.
▶️ Flavanol-rich foods may be efficacious nutritional strategies to counteract sitting-induced endothelial impairments during prolonged sitting in older adults,
pubs.rsc.org/fo/article/17/3… @guani_vic @DrRPalmquist @LoriShemek @_atanas_ @_INPST
@nuclearball @chidambara09
Two hours of sitting impaired upper & lower limb endothelial function (flow-mediated dilation; FMD) & increased blood pressure in healthy older adults. Consuming flavanols prior to sitting preserved endothelial function in both conduit arteries.
